PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

脂肪性肝炎 脂肪变性 内科学 肝活检 脂联素 医学 过氧化物酶体增殖物激活受体 内分泌学 胰岛素抵抗 活检 脂肪肝 纤维化 生物标志物 胃肠病学 酒精性肝炎 炎症 基因表达 病理 生物 受体 胰岛素 肥胖 疾病 生物化学
作者
Sven Francque,An Verrijken,Sandrine Caron,Janne Prawitt,Réjane Paumelle,Bruno Derudas,Philippe Lefèbvre,Marja‐Riitta Taskinen,Wim Van Hul,Ilse Mertens,Guy Hubens,Eric Van Marck,P. Michielsen,Luc Van Gaal,Bart Staels
出处
期刊:Journal of Hepatology [Elsevier]
卷期号:63 (1): 164-173 被引量:248
标识
DOI:10.1016/j.jhep.2015.02.019
摘要

Peroxisome proliferator-activated receptors (PPARs) have been implicated in non-alcoholic steatohepatitis (NASH) pathogenesis, mainly based on animal data. Gene expression data in NASH patients are scarce. We studied liver PPARα, β/δ, and γ expression in a large cohort of obese patients assessed for presence of NAFLD at baseline and 1 year follow-up.Patients presented to the obesity clinic underwent a hepatic work-up. If NAFLD was suspected, liver biopsy was performed. Gene expression was studied by mRNA quantification. Patients were reassessed after 1 year.125 patients were consecutively included in the study, of which 85 patients had paired liver biopsy taken at 1 year of follow-up. Liver PPARα expression negatively correlated with the presence of NASH (p=0.001) and with severity of steatosis (p=0.003), ballooning (p=0.001), NASH activity score (p=0.008) and fibrosis (p=0.003). PPARα expression was positively correlated to adiponectin (R(2)=0.345, p=0.010) and inversely correlated to visceral fat (R(2)=-0.343, p<0.001), HOMA IR (R(2)=-0.411, p<0.001) and CK18 (R(2)=-0.233, p=0.012). Liver PPARβ/δ and PPARγ expression did not correlate with any histological feature nor with glucose metabolism or serum lipids. At 1 year, correlation of PPARα expression with liver histology was confirmed. In longitudinal analysis, an increase in expression of PPARα and its target genes was significantly associated with histological improvement (p=0.008).Human liver PPARα gene expression negatively correlates with NASH severity, visceral adiposity and insulin resistance and positively with adiponectin. Histological improvement is associated with an increase in expression of PPARα and its target genes. These data might suggest that PPARα is a potential therapeutic target in NASH.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
YFW完成签到,获得积分10
1秒前
wu发布了新的文献求助10
1秒前
斯文败类应助tyra采纳,获得10
2秒前
2秒前
洛城完成签到,获得积分10
2秒前
4秒前
吴刀仔发布了新的文献求助30
4秒前
热心芹菜发布了新的文献求助10
4秒前
Yang完成签到 ,获得积分10
5秒前
6秒前
寒冷的觅露完成签到,获得积分10
6秒前
7秒前
54小甜发布了新的文献求助10
7秒前
大个应助先吃一只羊采纳,获得10
8秒前
zhang完成签到,获得积分10
8秒前
尹尹尹发布了新的文献求助10
9秒前
仁爱钢笔发布了新的文献求助50
11秒前
12秒前
keikei完成签到,获得积分10
12秒前
12秒前
14秒前
今天很美味完成签到 ,获得积分10
14秒前
盛夏光年完成签到,获得积分10
14秒前
15秒前
楚小镇完成签到,获得积分20
15秒前
15秒前
16秒前
文静冷梅完成签到,获得积分20
16秒前
斯文败类应助可咳咳咳采纳,获得10
16秒前
16秒前
盛夏光年发布了新的文献求助10
17秒前
hellzhu完成签到,获得积分10
17秒前
18秒前
哈哈哈发布了新的文献求助10
18秒前
小二郎应助碗碗采纳,获得10
19秒前
爱笑灵竹完成签到,获得积分10
19秒前
wang完成签到,获得积分20
21秒前
王小妖发布了新的文献求助10
21秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3256170
求助须知:如何正确求助?哪些是违规求助? 2898255
关于积分的说明 8300702
捐赠科研通 2567460
什么是DOI,文献DOI怎么找? 1394536
科研通“疑难数据库(出版商)”最低求助积分说明 652839
邀请新用户注册赠送积分活动 630511