中国仓鼠卵巢细胞
胞浆
甘露糖6-磷酸受体
细胞生物学
膜蛋白
溶酶体
生物化学
糖蛋白
体外
受体
蛋白质水解
生物
蛋白质降解
化学
酶
膜
作者
Ana María Cuervo,J. Fred Dice
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1996-07-26
卷期号:273 (5274): 501-503
被引量:906
标识
DOI:10.1126/science.273.5274.501
摘要
Multiple pathways of protein degradation operate within cells. A selective protein import pathway exists for the uptake and degradation of particular cytosolic proteins by lysosomes. Here, the lysosomal membrane glycoprotein LGP96 was identified as a receptor for the selective import and degradation of proteins within lysosomes. Specific substrates of this proteolytic pathway bound to the cytosolic tail of a 96-kilodalton lysosomal membrane protein in two different binding assays. Overexpression of human LGP96 in Chinese hamster ovary cells increased the activity of the selective lysosomal proteolytic pathway in vivo and in vitro.
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