前列环素
血栓素
自闭症
受体
生物化学
化学
前列腺素
酶
环氧合酶
激活剂(遗传学)
血栓素A2
前列腺素H2
生物合成
环化酶
前列腺素
生物
血小板
免疫学
出处
期刊:Annual Review of Physiology
[Annual Reviews]
日期:1979-10-01
卷期号:41 (1): 633-652
被引量:366
标识
DOI:10.1146/annurev.ph.41.030179.003221
摘要
With improved techniques for isolation and identification of materials, thromboxane (TXA2) and prostacyclin (PGI2) derivatives are now recognized as more abundant in some tissues and more potent than PGE2 and PGF2alpha. The rapid appearance and disappearance of these autacoids can be regulated at many points along the enzymatic path. Two important features affecting the rate of overall prostaglandin formation are the availability of non-esterified substrate and the availability of hydroperoxide activator for the cyclooxygenase. The fate of the endoperoxide formed by this reaction then depends upon the different relative amounts of the synthases and dehydrogenases in each type of synthesizing cell. Important future developments will indicate ways in which the amounts of these enzyme activities are altered and the ways in which the prostaglandin receptors interact with cellular adenyl cyclase and adrenergic receptors.
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