冰片
脂质体
Zeta电位
药理学
多糖
色谱法
化学
材料科学
医学
纳米颗粒
生物化学
纳米技术
中医药
病理
替代医学
作者
Huang Ding,Ke Wang,Lin-Qin He,Xiaoyu Yang,Haihong Huang,Wenlong Liu,Xiao Chen,Ze- Xuan Du,Lian- Yu,Wei Zhang
标识
DOI:10.1080/08982104.2022.2106240
摘要
To investigate the preparation of novel nanoliposomes (Borneol Angelica Polysaccharide Liposomes, BAPL) for anti-cerebral ischaemia and verify its curative effects and mechanism.By applying a uniform experiment design to investigate the fitting combination of BAPL. Encapsulation Efficiency Evaluation of BAPL Preparation; Particle Size and Surface Potential Evaluation of BAPL Biological activity; Cerebral ischaemia models of rats Evaluation of BAPL curative effects and mechanism.(1) The fitting combination of lecithin, Cholesterol, AP mass and the borneol mass was 60 mg, 60 mg, 45 mg and 5 mg. the highest encapsulation efficiency was 80.4%, the particle size was 179.1 nm, and the surface zeta potential was -17.2 mV. It conforms to the nano-material standards. (2) The results of animal experiments show that: In the BAPL group, the infarct volume of TTC staining was significantly decreased, and the expression levels of NF-κBp65, TLR-4, IL-8, IL-6, IL-1β in brain tissue were significantly decreased, while the expression levels of ZO-1, ZO-2, IL-10 were significantly increased after cerebral ischaemia-reperfusion.BAPL is a novel nano and effective material for anti-cerebral ischaemia.
科研通智能强力驱动
Strongly Powered by AbleSci AI