生物医学中的光声成像
光学成像
分子成像
模态(人机交互)
发色团
信号(编程语言)
临床前影像学
小分子
体内
纳米技术
光声光谱学
材料科学
化学
计算机科学
光学
生物
光化学
生物化学
生物技术
物理
程序设计语言
人机交互
作者
Jean Michél Merkes,Fabian Kießling,Srinivas Banala
标识
DOI:10.2174/0929867329666220208093735
摘要
Photoacoustic imaging (PAI) is a non-invasive modality for molecular imaging and is on the way to becoming a routine clinical diagnostic tool. The advantage of PAI over many other currently used modalities is its ability to potentially image in vivo a variety of enzymatic and physiological processes as well as metabolites in real time at high tissue depths. For this purpose, photoacoustic signal generating chromophores, which have the ability to change their signal characteristics upon reaction, to their environments or trapping reactive species, are important. This review article provides an overview of the concepts for activatable small molecule probes for photoacoustic imaging, highlights the requirements for structural and optical properties, and describes their responses to the selective triggers.
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