Alveolar Macrophage P2Y6 Receptor Signaling Regulates NFATC2 Activation to Enhance Protective Innate Immune Responses

Alveolar macrophage P2Y6 receptor signaling prevents adaptive type 2 allergic inflammation through the enhancement of IL-12 production by alveolar macrophage during the innate phase of dust mite exposure. However, the mechanisms through which alveolar macrophage P2Y6 receptors facilitate IL-12 production and reinforce the innate immune response is still unknown.