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A biodegradable in situ Zn–Mg2Ge composite for bone-implant applications

材料科学 极限抗拉强度 复合数 生物相容性 复合材料 腐蚀 金属间化合物 生物降解 冶金 有机化学 化学 合金
作者
Xian Tong,Hongning Wang,Li Zhu,Yue Han,Kun Wang,Yuncang Li,Jianfeng Ma,Jixing Lin,Cuié Wen,Shengbin Huang
出处
期刊:Acta Biomaterialia [Elsevier]
卷期号:146: 478-494 被引量:24
标识
DOI:10.1016/j.actbio.2022.05.017
摘要

Zinc (Zn)-based composites have received extensive attention as promising biodegradable materials due to their unique combination of moderate biodegradability, biocompatibility, and functionality. Nevertheless, the low mechanical strength of as-cast Zn-based composites impedes their practical clinical application. Here we reported the mechanical properties, corrosion behavior, wear properties, and cytotoxicity of in situ synthesized biodegradable Zn-xMg2Ge (x = 1, 3, and 5 wt.%) composites for bone-implant applications. The mechanical properties of Zn-xMg2Ge composites were effectively improved by alloying and hot-rolling due to particle reinforcement of the Mg2Ge intermetallic phase and dynamic recrystallization. The hot-rolled (HR) Zn-3Mg2Ge composite exhibited the best mechanical properties, including a yield strength of 162.3 MPa, an ultimate tensile strength of 264.3 MPa, an elongation of 10.9%, and a Brinell hardness of 83.9 HB. With an increase in Mg2Ge content, the corrosion and degradation rates of the HR Zn-xMg2Ge composites gradually increased, while their wear rate decreased and then increased in Hanks' solution. The diluted extract (12.5% concentration) of the HR Zn-3Mg2Ge composite showed the highest cell viability compared to the other HR composites and their as-cast pure Zn counterparts. Overall, the HR Zn-3Mg2Ge composite can be considered a promising biodegradable Zn-based composite for bone-implant applications. STATEMENT OF SIGNIFICANCE: This paper reports the mechanical properties, corrosion behavior, wear properties, and cytotoxicity of in situ synthesized biodegradable Zn-xMg2Ge (x = 1, 3, and 5 wt.%) composites for bone-implant applications. Our findings demonstrated that the mechanical properties of Zn-xMg2Ge composites were effectively improved by alloying and hot-rolling due to Mg2Ge particle reinforcement and dynamic recrystallization. The hot-rolled Zn-3Mg2Ge composite showed superior cytocompatibility, satisfying corrosion and degradation rates, and the best mechanical properties including a yield strength of 162.3 MPa, an ultimate tensile strength of 264.3 MPa, and an elongation of 10.9%.
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