RETRACTED: Identification of CD4 + T-Cell-Derived CD161 + CD39 + and CD39 + CD73 + Microparticles As New Biomarkers for Rheumatoid Arthritis

This study aimed to identify CD4+ T-cell-derived microparticles (MPs) and investigate their roles in rheumatoid arthritis (RA).Synovial fluids from 34 RA, 33 osteoarthritis patients and 42 healthy individuals were analyzed by flow cytometry. Human fibroblast-like synoviocytes and peripheral blood mononuclear cells were cultured with or without isolated MPs, chemokines and cytokines were measured by ELISA.CD4+CD161+CD39+ and CD4+CD39+CD73+ MPs were abundantly present in RA patients, which were positively or negatively correlated with RA features, respectively. Chemokines CCL20, CCL17 and CCL22, and cytokines IL-17 and IL-10 were influenced by these MPs in human fibroblast-like synoviocytes (HFLS) or PMBCs.CD4+ T-cell-derived CD161+CD39+ and CD39+CD73+ MPs could serve as new reciprocal biomarkers for RA evaluation.