电泳剂
烷基
亲核细胞
化学
有机合成
组合化学
过渡金属
分子
联轴节(管道)
催化作用
有机化学
计算化学
偶联反应
芳基
材料科学
冶金
作者
Junwon Choi,Gregory C. Fu
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2017-04-14
卷期号:356 (6334)
被引量:707
标识
DOI:10.1126/science.aaf7230
摘要
Because the backbone of most organic molecules is composed primarily of carbon-carbon bonds, the development of efficient methods for their construction is one of the central challenges of organic synthesis. Transition metal-catalyzed cross-coupling reactions between organic electrophiles and nucleophiles serve as particularly powerful tools for achieving carbon-carbon bond formation. Until recently, the vast majority of cross-coupling processes had used either aryl or alkenyl electrophiles as one of the coupling partners. In the past 15 years, versatile new methods have been developed that effect cross-couplings of an array of alkyl electrophiles, thereby greatly expanding the diversity of target molecules that are readily accessible. The ability to couple alkyl electrophiles opens the door to a stereochemical dimension-specifically, enantioconvergent couplings of racemic electrophiles-that substantially enhances the already remarkable utility of cross-coupling processes.
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