小RNA
生物
马拉特1
软骨内骨化
Wnt信号通路
长非编码RNA
计算生物学
细胞生物学
遗传学
核糖核酸
信号转导
基因
软骨
解剖
作者
Soudeh Ghafouri‐Fard,Atefe Abak,Shiva Tavakkoli Avval,Shayan Rahmani,Hamed Shoorei,Mohammad Taheri,Mohammad Samadian
标识
DOI:10.1016/j.biopha.2021.111942
摘要
Non-coding RNAs have been found to regulate several developmental processes among them is osteogenesis. Although these transcripts have several distinct classes, two classes i.e. microRNAs and long non-coding RNAs have attained more attention. These transcripts regulate intramembranous as well as endochondral ossification processes. The effects of microRNAs on osteogenesis are mostly mediated through modulation of Wnt/β-catenin and TGFβ/BMP pathways. Long non-coding RNAs can directly affect expression of these pathways or osteogenic transcription factors. Moreover, they can serve as a molecular sponge for miRNAs. MALAT1/miR-30, MALAt1/miR-214, LEF1-AS1/miR-24-3p, MCF2L-AS1/miR-33a, MSC-AS1/miR-140-5p and KCNQ1OT1/miR-214 are examples of such kind of interaction between lncRNAs and miRNAs in the context of osteogenesis. In the current paper, we explain these two classes of non-coding RNAs in the osteogenesis and related disorders.
科研通智能强力驱动
Strongly Powered by AbleSci AI