生物膜
抗菌肽
抗菌剂
微生物学
抗生素
生物
行动方式
药物输送
细菌
化学
计算生物学
生物化学
遗传学
有机化学
作者
Payal Gupta,Purusottam Mishra,Ramasare Prasad,Krishna Mohan Poluri
出处
期刊:Current Protein & Peptide Science
[Bentham Science]
日期:2021-03-22
卷期号:22
被引量:4
标识
DOI:10.2174/1389203722666210322145810
摘要
Microbial resistance to conventional therapeutics has become a significant threat to human society. Biofilms serve as the major virulence factor for the microorganisms by resisting the antibiotics and host innate immune system. Antimicrobial peptides (AMPs) have emerged as a potential alternative to conventional therapeutics due to their exceptional anti-biofilm and broad-spectrum antimicrobial property. Researchers have applied bioinformatics, genetic engineering, tissue culture, and drug delivery approaches to enhance the production and therapeutic efficacy of antimicrobial peptides. This review comprehensively describes the various aspects of AMPs with particular focus on their anti-biofilm potential. Other detailed information highlighted in this review includes different classes of AMPs, their mode of action, and anti-biofilm activity both alone and in synergy with other AMPs or conventional antibiotics. Further, challenges and opportunities of AMPs based drug delivery systems such as nano-formulations, polymeric micelles, and vesicles are also summarized.
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