Addressing Neurocognitive Late Effects in Pediatric Cancer Survivors: Current Approaches and Future Opportunities

Article Tools REVIEW ARTICLES Neurocognitive Outcomes in Survivors of Pediatric Cancer Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.20.02327 Journal of Clinical Oncology - published online before print April 22, 2021 PMID: 33886353 Addressing Neurocognitive Late Effects in Pediatric Cancer Survivors: Current Approaches and Future Opportunities Matthew C. Hocking , PhD1,2xMatthew C. HockingSearch for articles by this author; Karin S. Walsh, PsyD3,4xKarin S. WalshSearch for articles by this author; Kristina K. Hardy , PhD3,4xKristina K. HardySearch for articles by this author; and Heather M. Conklin , PhD5xHeather M. ConklinSearch for articles by this author Show More 1The Children's Hospital of Philadelphia, Philadelphia, PA2The University of Pennsylvania, Philadelphia, PA3Children's National Hospital, Washington, DC4The George Washington University School of Medicine, Washington, DC5Department of Psychology, St. Jude Children's Research Hospital, Memphis, TN https://doi.org/10.1200/JCO.20.02327 First Page Full Text PDF Figures and Tables © 2021 by American Society of Clinical OncologyCONTEXTKey ObjectiveIn this paper, we review empirical support for existing intervention approaches that address neurocognitive late effects among childhood cancer survivors.Knowledge GeneratedWe discuss the relative strengths, weaknesses, and potential next steps for five broad intervention domains: compensatory methods, pharmacologic interventions, in-person cognitive remediation, computerized approaches, and physical activity interventions. We also present opportunities for future intervention research including evaluating prevention efforts, the timing of intervention, the role of health behaviors, dosage and multicomponent interventions, risk-based approaches, and dissemination efforts.RelevanceWith a growing population of childhood cancer survivors, increased availability of feasible and efficacious interventions might help to mitigate neurocognitive late effects.AUTHOR CONTRIBUTIONSConception and design: All authorsCollection and assembly of data: All authorsManuscript writing: All authorsFinal approval of manuscript: All authorsAccountable for all aspects of the work: All authorsAUTHORS’ DISCLOSURES OF POTENTIAL CONFLICTS OF INTERESTAddressing Neurocognitive Late Effects in Pediatric Cancer Survivors: Current Approaches and Future OpportunitiesThe following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO’s conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/authors/author-center.Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).Karin S. WalshHonoraria: Novo NordiskConsulting or Advisory Role: Novo Nordisk, SpringworksResearch Funding: Novo NordiskTravel, Accommodations, Expenses: Novo NordiskKristina K. HardyEmployment: BayerHonoraria: BayerSpeakers' Bureau: BayerTravel, Accommodations, Expenses: BayerNo other potential conflicts of interest were reported.