Association of the Apolipoprotein E 2 Allele with Concurrent Occurrence of Endometrial Hyperplasia and Endometrial Carcinoma

子宫内膜增生 等位基因 子宫内膜癌 联想(心理学) 子宫内膜 医学 肿瘤科 内科学 生物 基因 遗传学 心理学 癌症 心理治疗师
作者
Т. И. Иванова,Л. И. Крикунова,Nikolay I. Ryabchenko,L. S. Mkrtchyan,Vera A. Khorokhorina,Lyubov E. Salnikova
出处
期刊:Oxidative Medicine and Cellular Longevity [Hindawi Limited]
卷期号:2015: 1-10 被引量:17
标识
DOI:10.1155/2015/593658
摘要

Genes encoding proteins with antioxidant properties may influence susceptibility to endometrial hyperplasia (EH) and endometrial carcinoma (ECa). Patients with EH ( n = 89), EH concurrent with ECa ( n = 76), ECa ( n = 186), and healthy controls ( n = 1110) were genotyped for five polymorphic variants in the genes involved in metabolism of lipoproteins ( APOE Cys112Arg and Arg158Cys), iron ( HFE Cys282Tyr and His63Asp), and catecholamines ( COMT Val158Met). Patients and controls were matched by ethnicity (all Caucasians), age, body mass index (BMI), and incidence of hypertension and diabetes. The frequency of the APOE E 2 allele (158Cys) was higher in patients with EH + ECa than in controls ( P = 0.0012,PBonferroni= 0.018, OR = 2.58, 95% CI 1.49–4.45). The APOE E 4 allele (112Arg) was more frequently found in patients with EH than in controls and HFE minor allele G (63Asp) had a protective effect in the ECa group, though these results appeared to be nonsignificant after correction for multiple comparisons. The results of the study indicate that E 2 allele might be associated with concurrent occurrence of EH and ECa.
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