保湿霜
酒渣鼻
医学
皮肤病科
经皮失水
敏感皮肤
红斑
清洁剂
角质层
皮肤干燥
甲硝唑
脱皮
磨皮术
痤疮
抗生素
病理
化学
食品科学
微生物学
生物
作者
Sabine Laquieze,Janusz Czernielewski,Eszter Baltás
标识
DOI:10.1080/09546630601121078
摘要
Introduction: Rosacea is a common and chronic disorder characterized by flushing, erythema, papules, pustules, and telangiectasia on the central part of the face. Because the facial skin of individuals with rosacea is particularly sensitive, irritants can trigger a worsening of the signs and symptoms of the disease. This enhanced sensitivity is thought to be linked to a deficient stratum corneum barrier function. Materials and methods: In the present study, 20 individuals receiving twice‐daily applications of metronidazole 0.75% gel for at least 15 days applied a gentle non‐irritating moisturizing cream (Cetaphil® Moisturizing Cream) twice daily for 15 days on one half of the face; the other side remained treated with metronidazole only and served as the control. Results: Clinical assessments, confirmed by biophysical measurements (electrical capacitance, transepidermal water loss (TEWL), and lactic acid stinging test), provided evidence that the moisturizer contributed to the restoration of the skin barrier: skin dryness, roughness and desquamation were much improved and skin sensitivity was significantly reduced. Skin properties and skin discomfort were also greatly enhanced and the patients were very satisfied with the product. Conclusions: It can thus be concluded that in the management of rosacea, basic skin care regimens, including daily use of a therapeutic moisturizer, offer optimal benefits.
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