亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Neurophysiology and Treatment of Disorders of Consciousness Induced by Traumatic Brain Injury: Orexin Signaling as a Potential Therapeutic Target

清醒 增食欲素 嗜睡症 外侧下丘脑 神经科学 持续植物状态 医学 网状激活系统 创伤性脑损伤 下丘脑 心理学 神经学 内科学 意识 网状结构 中枢神经系统 精神科 最小意识状态 脑电图 神经肽 受体
作者
Huiling Tang,Qiumei Zhu,Wei Li,Siru Qin,Yinan Gong,Hong Wang,Seiji Shioda,Shanshan Li,Jin Huang,Baohu Liu,Yuxin Fang,Yangyang Liu,Shenjun Wang,Yongming Guo,Qing Xia,Yi Guo,Zhifang Xu
出处
期刊:Current Pharmaceutical Design [Bentham Science]
卷期号:25 (39): 4208-4220 被引量:11
标识
DOI:10.2174/1381612825666191029101830
摘要

Traumatic brain injury (TBI) can cause disorders of consciousness (DOC) by impairing the neuronal circuits of the ascending reticular activating system (ARAS) structures, including the hypothalamus, which are responsible for the maintenance of the wakefulness and awareness. However, the effectiveness of drugs targeting ARAS activation is still inadequate, and novel therapeutic modalities are urgently needed.The goal of this work is to describe the neural loops of wakefulness, and explain how these elements participate in DOC, with emphasis on the identification of potential new therapeutic options for DOC induced by TBI.Hypothalamus has been identified as a sleep/wake center, and its anterior and posterior regions have diverse roles in the regulation of the sleep/wake function. In particular, the posterior hypothalamus (PH) possesses several types of neurons, including the orexin neurons in the lateral hypothalamus (LH) with widespread projections to other wakefulness-related regions of the brain. Orexins have been known to affect feeding and appetite, and recently their profound effect on sleep disorders and DOC has been identified. Orexin antagonists are used for the treatment of insomnia, and orexin agonists can be used for narcolepsy. Additionally, several studies demonstrated that the agonists of orexin might be effective in the treatment of DOC, providing novel therapeutic opportunities in this field.The hypothalamic-centered orexin has been adopted as the point of entry into the system of consciousness control, and modulators of orexin signaling opened several therapeutic opportunities for the treatment of DOC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
搜集达人应助科研通管家采纳,获得10
12秒前
14秒前
20秒前
橘涂完成签到 ,获得积分10
29秒前
调研昵称发布了新的文献求助10
53秒前
55秒前
无语发布了新的文献求助10
1分钟前
1分钟前
xpqiu完成签到,获得积分10
1分钟前
1分钟前
无语完成签到,获得积分20
1分钟前
Sooinlee完成签到,获得积分10
1分钟前
1分钟前
阿明发布了新的文献求助10
1分钟前
Nancy0818完成签到 ,获得积分10
2分钟前
Tirachen完成签到,获得积分10
2分钟前
Tirachen发布了新的文献求助10
2分钟前
情怀应助后会无期采纳,获得10
3分钟前
3分钟前
动听乐萱发布了新的文献求助10
3分钟前
科目三应助动听乐萱采纳,获得10
3分钟前
3分钟前
后会无期发布了新的文献求助10
3分钟前
wizardz完成签到 ,获得积分10
4分钟前
4分钟前
陌路完成签到,获得积分10
4分钟前
科研搬运工完成签到,获得积分10
4分钟前
陌路发布了新的文献求助10
4分钟前
CATH完成签到 ,获得积分10
4分钟前
4分钟前
4分钟前
zzz2193发布了新的文献求助10
4分钟前
华仔应助后会无期采纳,获得10
5分钟前
城南烤地瓜完成签到 ,获得积分10
5分钟前
5分钟前
5分钟前
iehaoang完成签到 ,获得积分10
5分钟前
5分钟前
zzz完成签到 ,获得积分10
5分钟前
动听乐萱发布了新的文献求助10
5分钟前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Gerard de Lairesse : an artist between stage and studio 500
Digging and Dealing in Eighteenth-Century Rome 500
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3062985
求助须知:如何正确求助?哪些是违规求助? 2717920
关于积分的说明 7456576
捐赠科研通 2364178
什么是DOI,文献DOI怎么找? 1253324
科研通“疑难数据库(出版商)”最低求助积分说明 608499
版权声明 596552