SARS-CoV-2 in patients with chronic liver disease

S U r g e rY Antibiotics versus appendectomy for appendicitisTo assess the efficacy of antibiotic therapy compared with appendectomy for the treatment of appendicitis, a noninferiority trial in 1,552 adults with appendicitis or an appendicolith was conducted at 25 centres in the USA.Patients were randomized to receive either a 10-day course of antibiotics or to undergo surgery.Antibiotics were noninferior to appendectomy, based on the primary outcome of 30-day European Quality of Life-5 Dimensions questionnaire scores (mean difference, 0.01 points; 95% CI -0.001 to 0.03).Of the antibiotics group, 41% of those with an appendicolith and 25% of those without had undergone an appendectomy by 90 days after randomization.Complications were more common in the antibiotics group than in the appendectomy group.