Primary Results Of The REVEALPLAQUE Study: A Prospective Quantitative Assessment Of AI-based CCTA Plaque Volume Compared With IVUS

Introduction: Coronary plaque burden and composition are strong prognostic markers in patients with coronary artery disease, but direct validation of noninvasive plaque measures compared to invasive imaging reference standards employing convenient automated mechanisms are limited. The purpose of this study was to compare an AI-enabled quantitative plaque analysis (AI-PA) derived from coronary computed tomography angiography (CCTA) to intravascular ultrasound (IVUS).