生物
减数分裂
遗传学
泛素连接酶
四三肽
细胞周期
细胞分裂
有丝分裂
同源染色体
细胞生物学
减数分裂II
CDC20型
后期
泛素
基因
细胞
作者
Ting Zhang,Shuang‐Hui Zhao,Yan He
出处
期刊:Plant Journal
[Wiley]
日期:2023-12-04
卷期号:117 (5): 1517-1527
被引量:1
摘要
SUMMARY Elaborate cell‐cycle control must be adopted to ensure the continuity of the meiotic second division and termination after that. Despite its importance, however, the genetic controls underlying the meiotic cell cycle have not been reported in maize. Here, we characterized a meiotic cell‐cycle controller ZmTDM1 , which is a homolog of Arabidopsis TDM1 and encodes a canonical tetratricopeptide repeat domain protein in maize. The Zmtdm1 homozygous plants exhibited complete male sterility and severe female abortion. In Zmtdm1 mutants, cell‐cycle progression was almost identical to that of wild type from leptotene to anaphase II. However, chromosomes in the tetrad failed meiotic termination at the end of the second division and underwent additional divisions in succession without DNA replication, reducing the ploidy to less than haploid in the product. In addition, two ZmTDM1 ‐like homologs ( ZmTDML1 and ZmTDML2 ) were not functional in meiotic cell‐cycle control. Moreover, ZmTDM1 interacted with RING‐type E3 ubiquitin ligase, revealing that it acts as a subunit of the APC/C E3 ubiquitin ligase complex. Overall, our results identified a regulator of meiotic cell cycle in maize and demonstrated that ZmTDM1 is essential for meiotic exit after meiosis II.
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