Quantitative transcriptome‐based analysis predicts a combination therapy for severe haemophilia B: A case report

British Journal of HaematologyEarly View LETTER TO THE EDITOR Quantitative transcriptome-based analysis predicts a combination therapy for severe haemophilia B: A case report Jundong Zhang, Jundong Zhang orcid.org/0000-0001-7433-2479 Department of Hematology, Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, ChinaSearch for more papers by this authorHaoran Chen, Haoran Chen School of Management, Shanxi Medical University, Taiyuan, ChinaSearch for more papers by this authorLei Shi, Lei Shi Senior Department of Infectious Diseases, the Fifth Medical Center & National Clinical Research Center for Infectious Diseases, Chinese PLA General Hospital, Beijing, ChinaSearch for more papers by this authorYanping Ma, Yanping Ma Department of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaSearch for more papers by this authorPeng Zhi, Peng Zhi Medical School of Chinese PLA, Beijing, China Medical Big Data Research Center, Chinese PLA General Hospital, Beijing, ChinaSearch for more papers by this authorHongyi Li, Hongyi Li Medical School of Chinese PLA, Beijing, ChinaSearch for more papers by this authorHaojun Zhang, Haojun Zhang Basic Medicine College, Shanxi Medical University, Taiyuan, ChinaSearch for more papers by this authorJie Geng, Jie Geng Basic Medicine College, Shanxi Medical University, Taiyuan, ChinaSearch for more papers by this authorLi Zhong Zhang, Li Zhong Zhang Basic Medicine College, Shanxi Medical University, Taiyuan, ChinaSearch for more papers by this authorYu Jing, Yu Jing orcid.org/0000-0003-3644-3180 Department of Hematology, Fifth Medical Center, Chinese PLA General Hospital, Beijing, ChinaSearch for more papers by this authorXuechun Lu, Corresponding Author Xuechun Lu [email protected] orcid.org/0009-0006-2471-5125 Department of Hematology, Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, National Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, China Correspondence Xuechun Lu, Department of Hematology, Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China. Email: [email protected]Search for more papers by this author Jundong Zhang, Jundong Zhang orcid.org/0000-0001-7433-2479 Department of Hematology, Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, ChinaSearch for more papers by this authorHaoran Chen, Haoran Chen School of Management, Shanxi Medical University, Taiyuan, ChinaSearch for more papers by this authorLei Shi, Lei Shi Senior Department of Infectious Diseases, the Fifth Medical Center & National Clinical Research Center for Infectious Diseases, Chinese PLA General Hospital, Beijing, ChinaSearch for more papers by this authorYanping Ma, Yanping Ma Department of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaSearch for more papers by this authorPeng Zhi, Peng Zhi Medical School of Chinese PLA, Beijing, China Medical Big Data Research Center, Chinese PLA General Hospital, Beijing, ChinaSearch for more papers by this authorHongyi Li, Hongyi Li Medical School of Chinese PLA, Beijing, ChinaSearch for more papers by this authorHaojun Zhang, Haojun Zhang Basic Medicine College, Shanxi Medical University, Taiyuan, ChinaSearch for more papers by this authorJie Geng, Jie Geng Basic Medicine College, Shanxi Medical University, Taiyuan, ChinaSearch for more papers by this authorLi Zhong Zhang, Li Zhong Zhang Basic Medicine College, Shanxi Medical University, Taiyuan, ChinaSearch for more papers by this authorYu Jing, Yu Jing orcid.org/0000-0003-3644-3180 Department of Hematology, Fifth Medical Center, Chinese PLA General Hospital, Beijing, ChinaSearch for more papers by this authorXuechun Lu, Corresponding Author Xuechun Lu [email protected] orcid.org/0009-0006-2471-5125 Department of Hematology, Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, National Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, China Correspondence Xuechun Lu, Department of Hematology, Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China. Email: [email protected]Search for more papers by this author First published: 26 December 2023 https://doi.org/10.1111/bjh.19261 Jundong Zhang and Haoran Chen are the joint-first authors. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Open Research DATA AVAILABILITY STATEMENT Data of the patient presented here were applicable. Supporting Information Filename Description bjh19261-sup-0001-supinfo.zipZip archive, 71.6 KB Data S1. bjh19261-sup-0002-supinfo.docxWord 2007 document , 3 MB Appendix S1. bjh19261-sup-0003-VideoS1.mp4MPEG-4 video, 46.2 MB Video S1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. REFERENCES 1Leissinger C. Another victory for patients with hemophilia. N Engl J Med. 2023; 388(4): 372–373. 10.1056/NEJMe2216176 PubMedWeb of Science®Google Scholar 2Den Uijl IE, Mauser Bunschoten EP, Roosendaal G, Schutgens RE, Biesma DH, Grobbee DE, et al. Clinical severity of haemophilia a: does the classification of the 1950s still stand? Haemophilia. 2011; 17(6): 849–853. 10.1111/j.1365-2516.2011.02539.x CASPubMedWeb of Science®Google Scholar 3Lenting PJ, Denis CV, Christophe OD. 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