材料科学
脑组织
自愈水凝胶
生物医学工程
组织工程
创伤性脑损伤
复合数
复合材料
化学工程
医学
高分子化学
工程类
精神科
作者
Jingyu Wang,Yongrou Zhang,Zhiwei Lei,Junqi Wang,Yangming Zhao,Tao Lin Sun,Zhenyu Jiang,Licheng Zhou,Zejia Liu,Yiping Liu,Bao Yang,Liqun Tang
标识
DOI:10.1016/j.matdes.2023.112338
摘要
In surgical training and experimental research, brain tissues immersed in cerebrospinal fluid often exhibit complex deformation and strain rate effects that can compromise their reliability and stability. Therefore, it is essential to develop a high-fidelity human brain tissue simulant material that serves as a physical surrogate model to understand its mechanical behavior, such as traumatic brain injury (TBI). However, the existing simulant materials have failed to meet the required mechanical properties. This study presents a composite hydrogel consisting of both a rigid polysaccharides network (Sodium alginate and Pectin) and a flexible polyacrylamide network, exhibiting brain tissue-like mechanical properties under various solution environments and strain rates. The results show that nonlinear mechanical behavior and good similarity under various external environments (artificial cerebrospinal fluid, normal saline, deionized water, and air environments) and different strain rates (0.001 s−1,900 s−1,1700 s−1). By analyzing the experimental data and theoretical analysis, we examine the effects of complex environments on the mechanical behavior of composite hydrogel and porcine brain tissue. Given that the properties of human brain tissue resemble those of porcine brain tissue, our work has significant reference value in realizing surgical training and advancing related research in biomedical engineering.
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