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Contrast-enhanced US Evaluation of Hepatocellular Carcinoma Response to Chemoembolization: A Prospective Multicenter Trial

医学 肝细胞癌 放射科 前瞻性队列研究 多中心试验 多中心研究 实体瘤疗效评价标准 临床终点 核医学 临床试验 内科学 随机对照试验 临床研究阶段
作者
Esika Savsani,Colette M. Shaw,Flemming Forsberg,Corinne E. Wessner,Andrej Lyshchik,Patrick O’Kane,Ji‐Bin Liu,Rashmi Balasubramanya,Christopher G. Roth,Haresh Naringrekar,Scott W. Keith,Allison Tan,Kevin Anton,Kristen Bradigan,Jesse Civan,Susan M. Schultz,Susan Shamimi-Noori,Stephen Hunt,Michael C. Soulen,Robert F. Mattrey,Yuko Kono,John R. Eisenbrey
出处
期刊:Radiology [Radiological Society of North America]
卷期号:309 (1) 被引量:4
标识
DOI:10.1148/radiol.230727
摘要

Background Contrast-enhanced (CE) US has been studied for use in the detection of residual viable hepatocellular carcinoma (HCC) after locoregional therapy, but multicenter data are lacking. Purpose To compare two-dimensional (2D) and three-dimensional (3D) CE US diagnostic performance with that of CE MRI or CT, the current clinical standard, in the detection of residual viable HCC after transarterial chemoembolization (TACE) in a prospective multicenter trial. Materials and Methods Participants aged at least 21 years with US-visible HCC scheduled for TACE were consecutively enrolled at one of three participating academic medical centers from May 2016 to March 2022. Each underwent baseline 2D and 3D CE US before TACE, 2D and 3D CE US 1–2 weeks and/or 4–6 weeks after TACE, and CE MRI or CT 4–6 weeks after TACE. CE US and CE MRI or CT were evaluated by three fellowship-trained radiologists for the presence or absence of viable tumors and were compared with reference standards of pathology (18%), angiography on re-treatment after identification of residual disease at 1–2-month follow-up imaging (31%), 4–8-month CE MRI or CT (42%), or short-term (approximately 1–2 months) CE MRI or CT if clinically decompensated and estimated viability was greater than 50% at imaging (9%). Diagnostic performance criteria, including sensitivity and specificity, were obtained for each modality and time point with generalized estimating equation analysis. Results A total of 132 participants were included (mean age, 64 years ± 7 [SD], 87 male). Sensitivity of 2D CE US 4–6 weeks after TACE was 91% (95% CI: 84, 95), which was higher than that of CE MRI or CT (68%; 95% CI: 58, 76; P < .001). Sensitivity of 3D CE US 4–6 weeks after TACE was 89% (95% CI: 81, 94), which was higher than that of CE MRI or CT (P < .001), with no evidence of a difference from 2D CE US (P = .22). CE MRI or CT had 85% (95% CI: 76, 91) specificity, higher than that of 4–6-week 2D and 3D CE US (70% [95% CI: 56, 80] and 67% [95% CI: 53, 78], respectively; P = .046 and P = .023, respectively). No evidence of differences in any diagnostic criteria were observed between 1–2-week and 4–6-week 2D CE US (P > .21). Conclusion The 2D and 3D CE US examinations 4–6 weeks after TACE revealed higher sensitivity in the detection of residual HCC than CE MRI or CT, albeit with lower specificity. Importantly, CE US performance was independent of follow-up time. Clinical trial registration no. NCT02764801 © RSNA, 2023 Supplemental material is available for this article.
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