Contrast-enhanced US Evaluation of Hepatocellular Carcinoma Response to Chemoembolization: A Prospective Multicenter Trial

医学 肝细胞癌 放射科 前瞻性队列研究 多中心试验 多中心研究 实体瘤疗效评价标准 临床终点 核医学 临床试验 内科学 随机对照试验 临床研究阶段
作者
Esika Savsani,Colette M. Shaw,Flemming Forsberg,Corinne E. Wessner,Andrej Lyshchik,Patrick O’Kane,Ji‐Bin Liu,Rashmi Balasubramanya,Christopher G. Roth,Haresh Naringrekar,Scott W. Keith,Allison Tan,Kevin Anton,Kristen Bradigan,Jesse Civan,Susan M. Schultz,Susan Shamimi-Noori,Stephen Hunt,Michael C. Soulen,Robert F. Mattrey,Yuko Kono,John R. Eisenbrey
出处
期刊:Radiology [Radiological Society of North America]
卷期号:309 (1) 被引量:4
标识
DOI:10.1148/radiol.230727
摘要

Background Contrast-enhanced (CE) US has been studied for use in the detection of residual viable hepatocellular carcinoma (HCC) after locoregional therapy, but multicenter data are lacking. Purpose To compare two-dimensional (2D) and three-dimensional (3D) CE US diagnostic performance with that of CE MRI or CT, the current clinical standard, in the detection of residual viable HCC after transarterial chemoembolization (TACE) in a prospective multicenter trial. Materials and Methods Participants aged at least 21 years with US-visible HCC scheduled for TACE were consecutively enrolled at one of three participating academic medical centers from May 2016 to March 2022. Each underwent baseline 2D and 3D CE US before TACE, 2D and 3D CE US 1–2 weeks and/or 4–6 weeks after TACE, and CE MRI or CT 4–6 weeks after TACE. CE US and CE MRI or CT were evaluated by three fellowship-trained radiologists for the presence or absence of viable tumors and were compared with reference standards of pathology (18%), angiography on re-treatment after identification of residual disease at 1–2-month follow-up imaging (31%), 4–8-month CE MRI or CT (42%), or short-term (approximately 1–2 months) CE MRI or CT if clinically decompensated and estimated viability was greater than 50% at imaging (9%). Diagnostic performance criteria, including sensitivity and specificity, were obtained for each modality and time point with generalized estimating equation analysis. Results A total of 132 participants were included (mean age, 64 years ± 7 [SD], 87 male). Sensitivity of 2D CE US 4–6 weeks after TACE was 91% (95% CI: 84, 95), which was higher than that of CE MRI or CT (68%; 95% CI: 58, 76; P < .001). Sensitivity of 3D CE US 4–6 weeks after TACE was 89% (95% CI: 81, 94), which was higher than that of CE MRI or CT (P < .001), with no evidence of a difference from 2D CE US (P = .22). CE MRI or CT had 85% (95% CI: 76, 91) specificity, higher than that of 4–6-week 2D and 3D CE US (70% [95% CI: 56, 80] and 67% [95% CI: 53, 78], respectively; P = .046 and P = .023, respectively). No evidence of differences in any diagnostic criteria were observed between 1–2-week and 4–6-week 2D CE US (P > .21). Conclusion The 2D and 3D CE US examinations 4–6 weeks after TACE revealed higher sensitivity in the detection of residual HCC than CE MRI or CT, albeit with lower specificity. Importantly, CE US performance was independent of follow-up time. Clinical trial registration no. NCT02764801 © RSNA, 2023 Supplemental material is available for this article.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
LX77bx完成签到,获得积分10
3秒前
外向的醉易完成签到,获得积分10
4秒前
SharonDu完成签到 ,获得积分10
5秒前
6秒前
yuncong323完成签到,获得积分10
7秒前
huohuo完成签到,获得积分10
9秒前
CB完成签到,获得积分10
10秒前
10秒前
11秒前
儒雅路人完成签到,获得积分10
12秒前
OLDBLOW完成签到,获得积分10
13秒前
13秒前
liupangzi完成签到,获得积分10
13秒前
wang完成签到,获得积分10
13秒前
14秒前
Catherkk发布了新的文献求助10
14秒前
lcdamoy完成签到,获得积分10
15秒前
钱浩然发布了新的文献求助10
15秒前
烊烊发布了新的文献求助10
16秒前
十曰完成签到,获得积分10
21秒前
jjjjchou完成签到,获得积分10
22秒前
虚心的不二完成签到 ,获得积分10
24秒前
xuzj应助科研通管家采纳,获得10
25秒前
小马甲应助科研通管家采纳,获得10
25秒前
25秒前
思源应助科研通管家采纳,获得10
25秒前
25秒前
研友_VZG7GZ应助科研通管家采纳,获得10
25秒前
fang应助科研通管家采纳,获得10
25秒前
隐形曼青应助科研通管家采纳,获得10
25秒前
科研通AI5应助科研通管家采纳,获得10
25秒前
FashionBoy应助科研通管家采纳,获得10
25秒前
shiizii应助科研通管家采纳,获得10
25秒前
27秒前
火星上的雨莲完成签到,获得积分10
31秒前
开朗的绮山发布了新的文献求助150
31秒前
平淡远山发布了新的文献求助10
32秒前
热心市民小红花应助Roman采纳,获得10
33秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038235
求助须知:如何正确求助?哪些是违规求助? 3575992
关于积分的说明 11374009
捐赠科研通 3305760
什么是DOI,文献DOI怎么找? 1819276
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022