溃疡性结肠炎
免疫系统
橙皮素
医学
小檗碱
纳米载体
药理学
药品
纳米技术
免疫学
材料科学
疾病
内科学
病理
替代医学
橙皮苷
作者
Shan Gao,Haocheng Zheng,Shujing Xu,Jingwei Kong,Feng Gao,Zhijia Wang,Yuan Li,Ziqi Dai,Xinqi Jiang,Xia Ding,Haimin Lei
标识
DOI:10.1002/adhm.202301826
摘要
Abstract Ulcerative colitis (UC) is a chronic inflammatory illness affecting the colon and rectum, with current treatment methods being unable to meet the clinical needs of ulcerative colitis patients. Although nanomedicines are recognized as promising anti‐inflammatory medicines, their clinical application is limited by their high cost and unpredictable safety risks. This study reveals that two natural phytochemicals, berberine (BBR) and hesperetin (HST), self‐assemble directly to form binary carrier‐free multi‐functional spherical nanoparticles (BBR‐HST NPs) through noncovalent bonds involving electrostatic interactions, π–π stacking, and hydrogen bonding. Because of their synergistic anti‐inflammatory activity, berberine–hesperetin nanoparticles (BBR‐HST NPs) exhibit significantly better therapeutic effects on UC and inhibitory effects on inflammation than BBR and HST at the same dose by regulating the immune microenvironment and repairing the damaged intestinal barrier. Furthermore, BBR‐HST NPs exhibit good biocompatibility and biosafety. Thus, this study proves the potential of novel natural anti‐inflammatory nanoparticles as therapeutic agents for UC, which could promote the progress of drug development for UC and eventually benefit patients who suffering from it.
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