Peripheral nerve regeneration: a challenge far from being overcome

人文学科 艺术
作者
Rui Alvites,Bruna Lopes,André Coelho,Ana Colette Maurício
出处
期刊:Regenerative Medicine [Future Medicine]
卷期号:19 (4): 155-159 被引量:3
标识
DOI:10.2217/rme-2023-0072
摘要

Regenerative MedicineAhead of Print CommentaryPeripheral nerve regeneration: a challenge far from being overcomeRui Alvites, Bruna Lopes, André Coelho & Ana Colette MaurícioRui Alvites *Author for correspondence: E-mail Address: ruialvites@hotmail.comhttps://orcid.org/0000-0003-1945-6377Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Rua D. Manuel II, Apartado 55142, 4051–401 Porto, PortugalDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, No. 228, 4050–313 Porto, PortugalAssociate Laboratory for Animal & Veterinary Science (AL4AnimalS), 1300–477 Lisboa, PortugalInstituto Universitário de Ciências da Saúde (CESPU), Avenida Central de Gandra 1317, Gandra, 4585–116 Paredes, Portugal, Bruna Lopes https://orcid.org/0000-0002-8168-2415Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Rua D. Manuel II, Apartado 55142, 4051–401 Porto, PortugalDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, No. 228, 4050–313 Porto, PortugalAssociate Laboratory for Animal & Veterinary Science (AL4AnimalS), 1300–477 Lisboa, Portugal, André Coelho https://orcid.org/0000-0002-6934-9935Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Rua D. Manuel II, Apartado 55142, 4051–401 Porto, PortugalDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, No. 228, 4050–313 Porto, PortugalAssociate Laboratory for Animal & Veterinary Science (AL4AnimalS), 1300–477 Lisboa, Portugal & Ana Colette Maurício https://orcid.org/0000-0002-0018-9363Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Rua D. Manuel II, Apartado 55142, 4051–401 Porto, PortugalDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, No. 228, 4050–313 Porto, PortugalAssociate Laboratory for Animal & Veterinary Science (AL4AnimalS), 1300–477 Lisboa, PortugalPublished Online:3 Oct 2023https://doi.org/10.2217/rme-2023-0072AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: future opportunities for nerve regenerationlimitations in nerve regenerationperipheral nerve injuryperipheral nerve regenerationReferences1. Hussain G, Wang J, Rasul A, Anwar H, Qasim M, Zafar S et al. Current status of therapeutic approaches against peripheral nerve injuries: a detailed story from injury to recovery. Int. J. Bio. Sci. 16(1), 116 (2020).Crossref, CAS, Google Scholar2. Bergmeister KD, Große-Hartlage L, Daeschler SC, Rhodius P, Böcker A, Beyersdorff M et al. Acute and long-term costs of 268 peripheral nerve injuries in the upper extremity. PLOS ONE 15(4), e0229530 (2020).Crossref, Medline, CAS, Google Scholar3. Bage T, Power DM. Iatrogenic peripheral nerve injury: a guide to management for the orthopaedic limb surgeon. EFORT Open Rev. 6(8), 607 (2021).Crossref, Medline, Google Scholar4. Nagappan PG, Chen H, Wang D-Y. Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury. Military Medical Res. 7(1), 1–16 (2020).Crossref, Medline, Google Scholar5. Battiston B, Papalia I, Tos P, Geuna S. Peripheral nerve repair and regeneration research: a historical note. Int. Rev. Neurobiol. 87, 1–7 (2009).Crossref, Medline, Google Scholar6. Supra R, Agrawal DK. Peripheral Nerve Regeneration: Opportunities and Challenges. J. Spine Res. Surg. 5(1), 10 (2023).Crossref, Medline, Google Scholar7. Ronchi G, Fregnan F, Muratori L, Gambarotta G, Raimondo S. Morphological Methods to Evaluate Peripheral Nerve Fiber Regeneration: A Comprehensive Review. Int. J. Mol. Sci. 24(3), 1818 (2023).Crossref, Medline, CAS, Google Scholar8. Modrak M, Talukder MH, Gurgenashvili K, Noble M, Elfar JC. Peripheral nerve injury and myelination: potential therapeutic strategies. J. Neurosci. Res. 98(5), 780–795 (2020).Crossref, Medline, CAS, Google Scholar9. Bhandari P. Management of peripheral nerve injury. J. Orthopaedics and Trauma. 10(5), 862–866 (2019).CAS, Google Scholar10. Gordon T. Peripheral nerve regeneration and muscle reinnervation. Int. J. Mol. Sci. 21(22), 8652 (2020).Crossref, Medline, CAS, Google Scholar11. Kaneko A, Naito K, Nakamura S, Miyahara K, Goto K, Obata H et al. Influence of aging on the peripheral nerve repair process using an artificial nerve conduit. Exp. Therapeutic Med. 21(2), 1 (2021).Medline, Google Scholar12. Bosch-Queralt M, Fledrich R, Stassart RM. Schwann cell functions in peripheral nerve development and repair. Neurobiol. Dis. 176, 105952 (2023).Crossref, Medline, CAS, Google Scholar13. Navarro X, Vivó M, Valero-Cabré A. Neural plasticity after peripheral nerve injury and regeneration. Prog. Neurobiol. 82(4), 163–201 (2007).Crossref, Medline, CAS, Google Scholar14. Alvarez FJ, Rotterman TM, Akhter ET, Lane AR, English AW, Cope TC. Synaptic plasticity on motoneurons after axotomy: a necessary change in paradigm. Front. Mol. Neurosci. 13, 68 (2020).Crossref, Medline, CAS, Google Scholar15. Vijayavenkataraman S. Nerve guide conduits for peripheral nerve injury repair: a review on design, materials and fabrication methods. Acta biomaterialia. 106, 54–69 (2020).Crossref, Medline, CAS, Google Scholar16. Taylor CS, Haycock JW. Biomaterials and scaffolds for repair of the peripheral nervous system. Peripheral Nerve Tissue Engineering and Regeneration Springer, 245–79 (2022).Crossref, Google Scholar17. Behtaj S, Ekberg JA, St John JA. Advances in electrospun nerve guidance conduits for engineering neural regeneration. Pharmaceutics 14(2), 219 (2022).Crossref, Medline, CAS, Google Scholar18. Sasaki R, Watanabe Y, Yamato M, Okamoto T. Tissue-engineered nerve guides with mesenchymal stem cells in the facial nerve regeneration. Neurochem. Int. 148, 105062 (2021).Crossref, Medline, CAS, Google Scholar19. Kaplan HM, Mishra P, Kohn J. The overwhelming use of rat models in nerve regeneration research may compromise designs of nerve guidance conduits for humans. J. Mat. Sci.: Mat. Med. 26, 1–5 (2015).Crossref, CAS, Google Scholar20. Li A, Pereira C, Hill EE, Vukcevich O, Wang A. In vitro in vivo and ex vivo models for peripheral nerve injury and regeneration. Curr. Neuropharmacol. 20(2), 344–361 (2022).Crossref, Medline, CAS, Google Scholar21. Burrell JC, Browne KD, Dutton JL, Laimo FA, Das S, Brown DP et al. A porcine model of peripheral nerve injury enabling ultra-long regenerative distances: surgical approach, recovery kinetics, and clinical relevance. Neurosurgery 87(4), 833–846 (2020).Crossref, Medline, Google Scholar22. Alvites RD, Branquinho MV, Sousa AC et al. Establishment of a sheep model for hind limb peripheral nerve injury: common peroneal nerve. Int. J. Mol. Sci. 22(3), 1401 (2021).Crossref, Medline, Google Scholar23. Contreras E, Traserra S, Bolívar S, Forés J, Jose-Cunilleras E, Delgado-Martínez I et al. Repair of Long Peripheral Nerve Defects in Sheep: A Translational Model for Nerve Regeneration. Int. J. Mol. Sci. 24(2), 1333 (2023).Crossref, Medline, Google ScholarFiguresReferencesRelatedDetails Ahead of Print STAY CONNECTED Metrics Downloaded 25 times History Received 19 April 2023 Accepted 12 August 2023 Published online 3 October 2023 Information© 2023 Future Medicine LtdKeywordsfuture opportunities for nerve regenerationlimitations in nerve regenerationperipheral nerve injuryperipheral nerve regenerationAuthor contributionsAll the authors have contributed to this editorial.AcknowledgmentsRD Alvites acknowledges the Centro de Estudos de Ciência Animal (CECA), In-stituto de Ciências, Tecnologias e Agroambiente (ICETA), Porto University (UP), and Fundação para a Ciência e Tecnologia (FCT) for the funding and availability of all technical, structural and human resources necessary for the development of this work.Financial disclosureThe work was supported through the project UIDB/00211/2020 funded by FCT/MCTES through national funds, through the projects 2022.04501.PTDC (Olfabionerve – Olfactory Mucosa Mesenchymal Stem Cells and Biomaterials Promoting Peripheral Nerve Regeneration) and PTDC/EMD-EMD/2229/2020 (PRECOGFIL – Filamentos dentados pre-tensionados para correção transvaginal do prolapso do compartimento anterior e posterior) and through the PhD scholarship 2021.05265.BD (Bruna Lopes). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.Competing interests disclosureThe authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, stock ownership or options and expert testimony.Writing disclosureNo writing assistance was utilized in the production of this manuscript.PDF download

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
邹小静完成签到 ,获得积分20
1秒前
1秒前
1秒前
Aa123321完成签到,获得积分10
3秒前
3秒前
苗条青槐完成签到,获得积分10
4秒前
海绵宝宝发布了新的文献求助10
5秒前
luotao应助文静的海采纳,获得10
5秒前
123关注了科研通微信公众号
5秒前
NexusExplorer应助穆振家采纳,获得10
5秒前
CodeCraft应助超帅的斌斌采纳,获得10
5秒前
5秒前
7秒前
斯文败类应助高院士采纳,获得10
8秒前
yznfly应助aaa采纳,获得30
10秒前
北风完成签到,获得积分10
10秒前
10秒前
Lin完成签到,获得积分10
10秒前
11秒前
我要啃木头完成签到,获得积分10
11秒前
13秒前
科研通AI6应助迷途的羔羊采纳,获得10
13秒前
nie完成签到,获得积分10
14秒前
不安的芝麻完成签到 ,获得积分10
14秒前
14秒前
烟花应助发文章12138采纳,获得10
14秒前
14秒前
哈hahehe发布了新的文献求助10
14秒前
15秒前
15秒前
16秒前
16秒前
17秒前
sun发布了新的文献求助10
17秒前
zqgxiangbiye发布了新的文献求助10
18秒前
18秒前
骑驴找马发布了新的文献求助10
18秒前
行走人生发布了新的文献求助30
19秒前
所所应助123采纳,获得10
19秒前
小马甲应助执着的酒窝采纳,获得10
20秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Binary Alloy Phase Diagrams, 2nd Edition 8000
Encyclopedia of Reproduction Third Edition 3000
Comprehensive Methanol Science Production, Applications, and Emerging Technologies 2000
From Victimization to Aggression 1000
Translanguaging in Action in English-Medium Classrooms: A Resource Book for Teachers 700
Exosomes Pipeline Insight, 2025 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 计算机科学 有机化学 物理 生物化学 纳米技术 复合材料 内科学 化学工程 人工智能 催化作用 遗传学 数学 基因 量子力学 物理化学
热门帖子
关注 科研通微信公众号,转发送积分 5649821
求助须知:如何正确求助?哪些是违规求助? 4779250
关于积分的说明 15050421
捐赠科研通 4808796
什么是DOI,文献DOI怎么找? 2571853
邀请新用户注册赠送积分活动 1528134
关于科研通互助平台的介绍 1486877