Peripheral nerve regeneration: a challenge far from being overcome

人文学科 艺术
作者
Rui Alvites,Bruna Lopes,André Coelho,Ana Colette Maurício
出处
期刊:Regenerative Medicine [Future Medicine]
卷期号:19 (4): 155-159 被引量:3
标识
DOI:10.2217/rme-2023-0072
摘要

Regenerative MedicineAhead of Print CommentaryPeripheral nerve regeneration: a challenge far from being overcomeRui Alvites, Bruna Lopes, André Coelho & Ana Colette MaurícioRui Alvites *Author for correspondence: E-mail Address: ruialvites@hotmail.comhttps://orcid.org/0000-0003-1945-6377Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Rua D. Manuel II, Apartado 55142, 4051–401 Porto, PortugalDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, No. 228, 4050–313 Porto, PortugalAssociate Laboratory for Animal & Veterinary Science (AL4AnimalS), 1300–477 Lisboa, PortugalInstituto Universitário de Ciências da Saúde (CESPU), Avenida Central de Gandra 1317, Gandra, 4585–116 Paredes, Portugal, Bruna Lopes https://orcid.org/0000-0002-8168-2415Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Rua D. Manuel II, Apartado 55142, 4051–401 Porto, PortugalDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, No. 228, 4050–313 Porto, PortugalAssociate Laboratory for Animal & Veterinary Science (AL4AnimalS), 1300–477 Lisboa, Portugal, André Coelho https://orcid.org/0000-0002-6934-9935Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Rua D. Manuel II, Apartado 55142, 4051–401 Porto, PortugalDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, No. 228, 4050–313 Porto, PortugalAssociate Laboratory for Animal & Veterinary Science (AL4AnimalS), 1300–477 Lisboa, Portugal & Ana Colette Maurício https://orcid.org/0000-0002-0018-9363Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Rua D. Manuel II, Apartado 55142, 4051–401 Porto, PortugalDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, No. 228, 4050–313 Porto, PortugalAssociate Laboratory for Animal & Veterinary Science (AL4AnimalS), 1300–477 Lisboa, PortugalPublished Online:3 Oct 2023https://doi.org/10.2217/rme-2023-0072AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: future opportunities for nerve regenerationlimitations in nerve regenerationperipheral nerve injuryperipheral nerve regenerationReferences1. Hussain G, Wang J, Rasul A, Anwar H, Qasim M, Zafar S et al. Current status of therapeutic approaches against peripheral nerve injuries: a detailed story from injury to recovery. Int. J. Bio. Sci. 16(1), 116 (2020).Crossref, CAS, Google Scholar2. 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Schwann cell functions in peripheral nerve development and repair. Neurobiol. Dis. 176, 105952 (2023).Crossref, Medline, CAS, Google Scholar13. Navarro X, Vivó M, Valero-Cabré A. Neural plasticity after peripheral nerve injury and regeneration. Prog. Neurobiol. 82(4), 163–201 (2007).Crossref, Medline, CAS, Google Scholar14. Alvarez FJ, Rotterman TM, Akhter ET, Lane AR, English AW, Cope TC. Synaptic plasticity on motoneurons after axotomy: a necessary change in paradigm. Front. Mol. Neurosci. 13, 68 (2020).Crossref, Medline, CAS, Google Scholar15. Vijayavenkataraman S. Nerve guide conduits for peripheral nerve injury repair: a review on design, materials and fabrication methods. Acta biomaterialia. 106, 54–69 (2020).Crossref, Medline, CAS, Google Scholar16. Taylor CS, Haycock JW. Biomaterials and scaffolds for repair of the peripheral nervous system. Peripheral Nerve Tissue Engineering and Regeneration Springer, 245–79 (2022).Crossref, Google Scholar17. Behtaj S, Ekberg JA, St John JA. Advances in electrospun nerve guidance conduits for engineering neural regeneration. Pharmaceutics 14(2), 219 (2022).Crossref, Medline, CAS, Google Scholar18. Sasaki R, Watanabe Y, Yamato M, Okamoto T. Tissue-engineered nerve guides with mesenchymal stem cells in the facial nerve regeneration. Neurochem. Int. 148, 105062 (2021).Crossref, Medline, CAS, Google Scholar19. Kaplan HM, Mishra P, Kohn J. The overwhelming use of rat models in nerve regeneration research may compromise designs of nerve guidance conduits for humans. J. Mat. Sci.: Mat. Med. 26, 1–5 (2015).Crossref, CAS, Google Scholar20. Li A, Pereira C, Hill EE, Vukcevich O, Wang A. In vitro in vivo and ex vivo models for peripheral nerve injury and regeneration. Curr. Neuropharmacol. 20(2), 344–361 (2022).Crossref, Medline, CAS, Google Scholar21. Burrell JC, Browne KD, Dutton JL, Laimo FA, Das S, Brown DP et al. A porcine model of peripheral nerve injury enabling ultra-long regenerative distances: surgical approach, recovery kinetics, and clinical relevance. Neurosurgery 87(4), 833–846 (2020).Crossref, Medline, Google Scholar22. Alvites RD, Branquinho MV, Sousa AC et al. Establishment of a sheep model for hind limb peripheral nerve injury: common peroneal nerve. Int. J. Mol. Sci. 22(3), 1401 (2021).Crossref, Medline, Google Scholar23. Contreras E, Traserra S, Bolívar S, Forés J, Jose-Cunilleras E, Delgado-Martínez I et al. Repair of Long Peripheral Nerve Defects in Sheep: A Translational Model for Nerve Regeneration. Int. J. Mol. Sci. 24(2), 1333 (2023).Crossref, Medline, Google ScholarFiguresReferencesRelatedDetails Ahead of Print STAY CONNECTED Metrics Downloaded 25 times History Received 19 April 2023 Accepted 12 August 2023 Published online 3 October 2023 Information© 2023 Future Medicine LtdKeywordsfuture opportunities for nerve regenerationlimitations in nerve regenerationperipheral nerve injuryperipheral nerve regenerationAuthor contributionsAll the authors have contributed to this editorial.AcknowledgmentsRD Alvites acknowledges the Centro de Estudos de Ciência Animal (CECA), In-stituto de Ciências, Tecnologias e Agroambiente (ICETA), Porto University (UP), and Fundação para a Ciência e Tecnologia (FCT) for the funding and availability of all technical, structural and human resources necessary for the development of this work.Financial disclosureThe work was supported through the project UIDB/00211/2020 funded by FCT/MCTES through national funds, through the projects 2022.04501.PTDC (Olfabionerve – Olfactory Mucosa Mesenchymal Stem Cells and Biomaterials Promoting Peripheral Nerve Regeneration) and PTDC/EMD-EMD/2229/2020 (PRECOGFIL – Filamentos dentados pre-tensionados para correção transvaginal do prolapso do compartimento anterior e posterior) and through the PhD scholarship 2021.05265.BD (Bruna Lopes). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.Competing interests disclosureThe authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, stock ownership or options and expert testimony.Writing disclosureNo writing assistance was utilized in the production of this manuscript.PDF download

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