破损
分离(统计)
色谱法
材料科学
化学
复合材料
计算机科学
机器学习
作者
Cui Xi,Yaqin Huang,Zejun Hu,Peng Wu,Xiao Dong Chen
标识
DOI:10.1016/j.cep.2024.109763
摘要
A novel colon soft-elastic reactor (CSER), inspired by the human ascending colon and cecum, has been developed and investigated using a model product system. This CSER replicates the behavior of the ascending colon in humans, achieving both peristalsis and segmental propulsion. The design of the bionic colon model is based on silicone and adopts a bag-like structure resembling colon anatomy. Peristalsis and segmental propulsion are simulated using a unique mechano-electric setup. Varying the depth of rolling motion resulted in different breakages of agar gel particles. Increasing the squeezing depth of the rollers against the silicone wall from 70% to 100% led to an increase in small-sized particles (< 3.5 mm) from 6.5% to 66.7% of the total particle mass. Moreover, increasing the frequency of segmental propulsion from 3.3 to 38.6 times/h reduced the half-life (t1/2) of agar gel particles from 137.9 to 0.4 min. The t1/2 was significantly higher for the 3.0 wt% agar gel (207.4 min) compared to the 1.0 wt% agar gel (113.5 min). During CSER squeezing, solid agar gel particles move upward while liquid flows downward along the wall due to gravity. These findings demonstrate the CSER effectively simulates bottom-to-top chyme transport in the ascending colon.
科研通智能强力驱动
Strongly Powered by AbleSci AI