脂质代谢
鞘脂
糖尿病
脂滴
免疫系统
医学
疾病
肾
新陈代谢
胆固醇
重编程
机制(生物学)
脂代谢紊乱
内科学
生物信息学
内分泌学
生物
免疫学
生物化学
细胞
血脂
哲学
认识论
作者
Yi-Zhen Han,Bing Du,Xiaodong Zhu,Y. Wang,Huaiping Zheng,Weijing Liu
标识
DOI:10.3389/fendo.2024.1336402
摘要
Diabetic kidney disease (DKD), a significant complication associated with diabetes mellitus, presents limited treatment options. The progression of DKD is marked by substantial lipid disturbances, including alterations in triglycerides, cholesterol, sphingolipids, phospholipids, lipid droplets, and bile acids (BAs). Altered lipid metabolism serves as a crucial pathogenic mechanism in DKD, potentially intertwined with cellular ferroptosis, lipophagy, lipid metabolism reprogramming, and immune modulation of gut microbiota (thus impacting the liver-kidney axis). The elucidation of these mechanisms opens new potential therapeutic pathways for DKD management. This research explores the link between lipid metabolism disruptions and DKD onset.
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