Left bundle branch block–induced cardiomyopathy: A distinctive form of cardiomyopathy that might require a dedicated form of treatment

The His-Purkinje system is the ventricular component of the cardiac conduction system that orchestrates the electrical impulse propagation which underlies every contraction of the heart. It originates from the AV-node and runs down to the interventricular septum and subdivides into the left and right bundle branches. These major branches divide further and spread diffusely along the sub endocardium. [ [1] Tawara S. Das Reizleitungssystem des SäugetierherzensEine Anatomisch-Histologische Studie über das Atrioventrikularbündel und die Purkinjeschen Faden. Jena. 1906; 1: 1-2 Google Scholar ],[ [2] Durrer D. van Dam R.T.H. Freud G.E. et al. Total excitation of the isolated human heart. Circulation. 1970; https://doi.org/10.1161/01.CIR.41.6.899 Google Scholar ] Damage in one of those branches may result in impaired electrical conduction. Beyond conduction impairment: Unveiling the profound myocardial injury in left bundle branch blockHeart RhythmPreviewLeft bundle branch block (LBBB) represents a frequently encountered conduction system disorder. Despite its widespread occurrence, a continual dilemma persists regarding its intricate association with underlying cardiomyopathy and its pivotal role in the initiation of dilated cardiomyopathy. The pathologic alterations linked to LBBB-induced cardiomyopathy (LBBB-CM) have remained elusive. Full-Text PDF Open Access