肠易激综合征
纤维肌痛
慢性疼痛
医学
背景(考古学)
神经病理性疼痛
人口
伤害
Toll样受体
止痛药
干预(咨询)
生物信息学
免疫系统
神经科学
精神科
受体
心理学
先天免疫系统
免疫学
生物
麻醉
内科学
古生物学
环境卫生
作者
Erick J. Rodríguez‐Palma,Saúl Huerta de la Cruz,Ana M. Islas-Espinoza,Gabriela Castañeda‐Corral,Vinicio Granados‐Soto,Rajesh Khanna
出处
期刊:Pain
[Ovid Technologies (Wolters Kluwer)]
日期:2024-04-05
标识
DOI:10.1097/j.pain.0000000000003238
摘要
Nociplastic pain, characterized by abnormal pain processing without an identifiable organic cause, affects a significant portion of the global population. Unfortunately, current pharmacological treatments for this condition often prove ineffective, prompting the need to explore new potential targets for inducing analgesic effects in patients with nociplastic pain. In this context, toll-like receptors (TLRs), known for their role in the immune response to infections, represent promising opportunities for pharmacological intervention because they play a relevant role in both the development and maintenance of pain. Although TLRs have been extensively studied in neuropathic and inflammatory pain, their specific contributions to nociplastic pain remain less clear, demanding further investigation. This review consolidates current evidence on the connection between TLRs and nociplastic pain, with a specific focus on prevalent conditions like fibromyalgia, stress-induced pain, sleep deprivation-related pain, and irritable bowel syndrome. In addition, we explore the association between nociplastic pain and psychiatric comorbidities, proposing that modulating TLRs can potentially alleviate both pain syndromes and related psychiatric disorders. Finally, we discuss the potential sex differences in TLR signaling, considering the higher prevalence of nociplastic pain among women. Altogether, this review aims to shed light on nociplastic pain, its underlying mechanisms, and its intriguing relationship with TLR signaling pathways, ultimately framing the potential therapeutic role of TLRs in addressing this challenging condition.
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