Effect of Pharmacotherapy for Overactive Bladder on the Incidence of and Factors Related to Urinary Tract Infection: A Systematic Review and Meta-analysis

膀胱过度活动 排尿困难 医学 泌尿科 泌尿系统 安慰剂 下尿路症状 药物治疗 科克伦图书馆 内科学 入射(几何) 随机对照试验 病理 替代医学 前列腺 癌症 物理 光学
作者
Kazuna Tsubouchi,Hisatomi Arima,Makiko Abe,Hiroshi Matsuzaki,Kosuke Tominaga,Aiko Fujikawa,Naotaka Gunge,Takeshi Miyazaki,Yu Okabe,Nobuyuki Nakamura,Hirofumi Matsuoka,Shota Okutsu,Kazuhiro Tada,Nobuhiro Haga
出处
期刊:The Journal of Urology [Lippincott Williams & Wilkins]
卷期号:209 (4): 665-674 被引量:5
标识
DOI:10.1097/ju.0000000000003209
摘要

The aim of this meta-analysis was to investigate the effect of pharmacotherapy for overactive bladder on the pathogenesis of urinary tract infection.A comprehensive search was performed in MEDLINE and the Cochrane Library using terms for overactive bladder, antimuscarinic agents, and beta 3-adrenoceptor agonists. The primary end point was the emergence of urinary tract infection after pharmacotherapy for overactive bladder. The secondary end point was the emergence of urinary retention, dysuria, and/or increased residual urine volume after overactive bladder treatment. Meta-analyses were conducted using random-effects models.A total of 35,939 patients in 33 trials (29 trials of antimuscarinic agents vs placebo, and 9 trials of beta 3-adrenoceptor agonists vs placebo) that included patients with overactive bladder were identified. At 1-3 months after treatment, the incidence of urinary tract infections was statistically significantly higher in the patients treated with antimuscarinic agents (RR: 1.23, 95% CI: 1.04, 1.45; P = .013) than in the placebo control group. The incidence of urinary tract infections was not increased in the patients treated with beta 3-adrenoceptor agonists (RR: 1.04, 95% CI: 0.76, 1.42; P = .796). Antimuscarinic agents also statistically significantly increased the risks of urinary retention, dysuria, and/or increased residual urine volume (RR: 2.88, 95% CI: 1.79, 4.63; P < .001), whereas beta 3-adrenoceptor agonists did not (RR: 1.26, 95% CI: 0.38, 4.14; P = .708).This meta-analysis showed that antimuscarinic agents statistically significantly increased the incidences of urinary tract infection and lower urinary tract symptoms and dysfunction, but beta 3-adrenoceptor agonists did not. To prevent urinary tract infection emergence, beta 3-adrenoceptor agonists might be safer than antimuscarinic agents.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
LaFee完成签到,获得积分10
刚刚
鑫鑫完成签到,获得积分10
刚刚
甚也完成签到 ,获得积分10
刚刚
ZZH完成签到,获得积分10
1秒前
mr完成签到 ,获得积分10
2秒前
今何在完成签到,获得积分10
2秒前
GY916完成签到 ,获得积分20
2秒前
Fly完成签到 ,获得积分10
3秒前
科目三应助黄超超采纳,获得10
3秒前
量子星尘发布了新的文献求助10
4秒前
Jason完成签到,获得积分10
5秒前
5秒前
歪比巴卜完成签到,获得积分10
6秒前
卿卿完成签到,获得积分20
7秒前
云墨完成签到 ,获得积分10
7秒前
SilentStorm完成签到,获得积分10
7秒前
8秒前
9秒前
sunnyfriend完成签到,获得积分10
9秒前
xiaozang完成签到,获得积分10
10秒前
怕黑寻雪完成签到 ,获得积分10
10秒前
11秒前
李白完成签到,获得积分10
12秒前
正直涵菱发布了新的文献求助10
12秒前
感性的酬海完成签到,获得积分10
13秒前
王王的狗子完成签到 ,获得积分10
13秒前
innyjiang完成签到,获得积分10
15秒前
陆王牛马完成签到 ,获得积分10
16秒前
16秒前
Ava应助念念采纳,获得10
17秒前
LIAO完成签到,获得积分10
17秒前
迅速凝竹完成签到 ,获得积分10
19秒前
妮妮完成签到,获得积分10
20秒前
20秒前
哈哈哈完成签到,获得积分20
21秒前
快乐随心完成签到 ,获得积分10
22秒前
了一李完成签到 ,获得积分10
22秒前
fqk完成签到,获得积分10
22秒前
活泼新儿完成签到,获得积分10
22秒前
23秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029