Modified Alendronate Mitigates Mechanical Degradation of the Rotator Cuff in an Osteoporotic Ovine Model

医学 热情 肩袖 肩膀 骨质疏松症 骨矿物 肌腱 生物力学 双膦酸盐 外科 内科学 泌尿科 牙科 解剖
作者
James Weldon Johnson,Devin von Stade,Benjamin C. Gadomski,Jeremiah T. Easley,Brad B. Nelson,Katie T. Bisazza,Daniel P. Regan,Kevin L. Troyer,Tianjian Zhou,Kirk C. McGilvray
出处
期刊:American Journal of Sports Medicine [SAGE Publishing]
卷期号:50 (13): 3649-3659 被引量:4
标识
DOI:10.1177/03635465221125175
摘要

Osteoporosis is an independent risk factor for failure after arthroscopic rotator cuff repair. Since rerupture rates after rotator cuff repair are associated with decreased bone mineral density and bone microarchitecture, adaptations of biomechanical properties of the rotator cuff enthesis in patients with osteoporosis remain unclear. Additionally, the effects of osteogenic therapy carrier drugs used for the treatment of osteoporosis on rotator cuff structure and properties have not been previously documented.To investigate the changes to soft tissue biomechanics and insertional structure secondary to osteoporosis with and without an osteogenic therapy carrier (ie, modified alendronate).Controlled laboratory study.Biomechanical, histopathological, and microcomputed tomography analyses were performed on 20 shoulders obtained from 10 osteoporotic sheep randomly allocated to modified bisphosphonate (ie, alendronate) or control (ie, osteoporotic without treatment) groups; 6 shoulders from healthy sheep were utilized for comparison purposes.Tendons from the control group exhibited a 57% decrease in undeformed Young modulus as compared with the healthy group (P = .010). Tendons from the modified bisphosphonate treatment group exhibited a 229% increase in initial Young modulus as compared with the control group (P = .010). Marked changes within the tendon insertional organization were noted in both the control and the modified bisphosphonate treatment group samples as evidenced by increased interdigitation of the bone-mineralized fibrocartilaginous junction. The control samples exhibited a markedly paucicellular insertion, whereas the modified bisphosphonate treated tendons exhibited a hypercellular insertional region as compared with the healthy group. Both groups exhibited significantly (P < .01) decreased bone quality underlying the infraspinatus insertion, as evidenced by all microcomputed tomography outcome parameters.This work illuminates changes to rotator cuff tendon secondary to osteoporosis. Specifically, it revealed decreased tendon modulus and altered insertional structure in the osteoporotic samples. Secondarily, these data revealed increases in tendon modulus accompanied by increased cellularity within the tendon insertion region after systemic modified bisphosphonate injections.Bisphosphonate treatment may have a positive effect on the healing of the enthesis after rotator cuff repair.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
xinxiangshicheng完成签到 ,获得积分10
刚刚
刘奶奶的牛奶完成签到,获得积分10
刚刚
清爽盼秋完成签到,获得积分10
刚刚
sunyanghu369发布了新的文献求助10
刚刚
1秒前
清蒸可达鸭完成签到,获得积分10
1秒前
锥子完成签到,获得积分10
1秒前
白色的风车发布了新的文献求助200
1秒前
机会啊完成签到,获得积分10
2秒前
123456完成签到,获得积分10
2秒前
迷路的鸽子完成签到,获得积分10
2秒前
苹果王子6699完成签到 ,获得积分10
3秒前
hani完成签到,获得积分10
4秒前
5秒前
激动的xx关注了科研通微信公众号
5秒前
6秒前
柠檬发布了新的文献求助10
7秒前
夸克的诗意完成签到,获得积分10
7秒前
无花果应助yy湫采纳,获得10
7秒前
7秒前
xlj完成签到,获得积分10
7秒前
清欢完成签到,获得积分10
7秒前
土土完成签到,获得积分10
8秒前
滕遥完成签到,获得积分10
8秒前
木木完成签到,获得积分10
9秒前
Oz完成签到,获得积分10
9秒前
迷人耗子精完成签到,获得积分10
9秒前
Shark完成签到,获得积分10
9秒前
Hello应助leo采纳,获得10
10秒前
沙力VAN完成签到,获得积分10
10秒前
gelinhao完成签到,获得积分10
10秒前
正经大善人完成签到,获得积分10
10秒前
CR7应助zhuww采纳,获得20
11秒前
11秒前
12秒前
赖建琛完成签到 ,获得积分10
12秒前
一叶知秋完成签到 ,获得积分10
12秒前
龙傲天完成签到,获得积分10
13秒前
liii完成签到,获得积分10
13秒前
醒不来的猫完成签到,获得积分10
14秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
A new approach to the extrapolation of accelerated life test data 1000
Coking simulation aids on-stream time 450
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 360
Novel Preparation of Chitin Nanocrystals by H2SO4 and H3PO4 Hydrolysis Followed by High-Pressure Water Jet Treatments 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4015859
求助须知:如何正确求助?哪些是违规求助? 3555835
关于积分的说明 11318981
捐赠科研通 3288954
什么是DOI,文献DOI怎么找? 1812355
邀请新用户注册赠送积分活动 887882
科研通“疑难数据库(出版商)”最低求助积分说明 812027