人参
乙酰胆碱酯酶
化学
阿切
氧化应激
胆碱乙酰转移酶
药理学
标记法
细胞凋亡
皂甙
神经保护
胆碱能的
半乳糖
PI3K/AKT/mTOR通路
生物化学
乙酰胆碱
酶
医学
内分泌学
替代医学
病理
作者
Yongbo Liu,Da-zhong Sun,Ke‐cheng Chen,Junjie Zhang,Yun‐yi Hou,Xu-fei Gao,Enbo Cai,Hongyan Zhu,Yinan Zheng,Rixin Chen,Shuang Liu,Wei Li
标识
DOI:10.1016/j.jff.2022.105224
摘要
The present study investigated the protective effects of crude saponins (ginsenosides) in berries in an brain injury model by intraperitoneal injection of D-gal (D-galactose). Our study showed that ginseng berry saponin (GBS) treatment significantly improved memory impairment in mice. Meanwhile, long-term exposure to D-gal reduces the expression of cholinergic modulators such as choline acetyltransferase (ChAT) and acetylcholinesterase (AChE), which can be significantly improved after administration. Furthermore, we found that GBS improved redox levels in the brain. In addition, TUNEL staining results showed that GBS inhibited D-Gal-induced apoptosis. Finally, we found that GBS treatment delayed cell aging by modulating the expression levels of cyclin D1 and senescence proteins p16 and p21, and further attenuated oxidative stress by activating SIRT1/Akt pathway. These results suggest that GBS can effectively treat D-Gal-induced brain damage and may be a potential therapeutic agent for slowing down the aging process.
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