脂肪组织
血管周围间隙
病理
生物
解剖
内科学
内分泌学
医学
作者
Marie Hanscom,Wilmarie Morales‐Soto,Stephanie W. Watts,William F. Jackson,Brian D. Gulbransen
出处
期刊:American Journal of Physiology-heart and Circulatory Physiology
[American Physiological Society]
日期:2024-07-01
卷期号:327 (1): H155-H181
标识
DOI:10.1152/ajpheart.00041.2024
摘要
This study challenges prevailing views on neural innervation in perivascular adipose tissue (PVAT) and its role in adrenergic-driven anticontractile effects on vasculature. Contrary to existing paradigms, limited anatomical and functional connections were found between PVAT nerve fibers and adipocytes, underscoring the importance of exploring alternative mechanistic pathways. Understanding the mechanisms involved in PVAT’s anticontractile effects is critical for developing potential therapeutic interventions against dysregulated vascular tone, hypertension, and cardiovascular disease.
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