光热治疗
材料科学
纳米技术
光动力疗法
肿瘤微环境
药物输送
生物相容性
常用化疗药物
纳米颗粒
癌细胞
癌症研究
癌症
化学
医学
肿瘤细胞
有机化学
内科学
冶金
作者
Masoud Nejabat,Ali Samie,Amir Khojastehnezhad,Farzin Hadizadeh,Mohammad Ramezani,Mona Alibolandi,Khalil Abnous,Seyed Mohammad Taghdisi,Mohamed Siaj
标识
DOI:10.1021/acsami.4c07040
摘要
Chemotherapy as a common anticancer therapeutic modality is often challenged by various obstacles such as poor stability, low solubility, and severe side effects of chemotherapeutic agents as well as multidrug resistance of cancerous cells. Nanoparticles in the role of carriers for chemotherapeutic drugs and platforms for combining different therapeutic approaches have effectively participated in overcoming such drawbacks. In particular, nanoparticles able to induce their therapeutic effect in response to specific stimuli like tumor microenvironment characteristics (e.g., hypoxia, acidic pH, high levels of glutathione, and overexpressed hydrogen peroxide) or extrinsic stimulus of laser light bring about more precise and selective treatments. Among them, nanostructures of covalent organic frameworks (COFs) have drawn great interest in biomedical fields during recent years. Possessing large surface area, high porosity, structural stability, and customizable architecture, these biocompatible porous crystalline polymers properly translate to promising platforms for drug delivery and induction of combination therapies. With the focus on stimuli-responsive characteristics of nanoscale COFs, this study aims to propose an overview of their potentiality in cancer treatment on the basis of chemotherapy alone or in combination with sonodynamic, chemodynamic, photodynamic, and photothermal therapies.
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