亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Neuroretinal Alterations in Schizophrenia and Bipolar Disorder: An Updated Meta-analysis

视网膜 神经纤维层 眼科 视网膜 双相情感障碍 精神分裂症(面向对象编程) 医学 荟萃分析 视网膜病变 脉络膜 心理学 神经科学 精神科 内科学 认知
作者
Nora Sheehan,Deepthi Bannai,Steven M. Silverstein,Paulo Lizano
出处
期刊:Schizophrenia Bulletin [Oxford University Press]
卷期号:50 (5): 1067-1082 被引量:10
标识
DOI:10.1093/schbul/sbae102
摘要

Abstract Schizophrenia (SZ) and bipolar disorder (BD) are characterized by major symptomatic, cognitive, and neuroanatomical changes. Recent studies have used optical coherence tomography (OCT) to investigate retinal changes in SZ and BD, but their unique and shared changes require further evaluation. Articles were identified using PubMed and Google Scholar. 39 studies met the inclusion criteria. Diagnostic groups were proband (SZ/BD combined), SZ, BD, and healthy control (HC) eyes. Meta-analyses utilized fixed and random effects models when appropriate, and publication bias was corrected using trim-and-fill analysis (“meta” package in R). Results are reported as standardized mean differences with 95% CIs. Data from 3145 patient eyes (1956 SZ, 1189 BD) and 3135 HC eyes were included. Studies identified thinning of the peripapillary retinal nerve fiber layer (pRNFL, overall and in 2 subregions), m-Retina (overall and all subregions), mGCL-IPL, mIPL, and mRPE in SZ patients. BD showed thinning of the pRNFL (overall and in each subregion), pGCC, and macular Retina (in 5 subregions), but no changes in thickness or volume for the total retina. Neither SZ nor BD patients demonstrated significant changes in the fovea, mRNFL, mGCL, mGCC, mINL, mOPL, mONL, or choroid thicknesses. Moderating effects of age, illness duration, and smoking on retinal structures were identified. This meta-analysis builds upon previous literature in this field by incorporating recent OCT studies and examining both peripapillary and macular retinal regions with respect to psychotic disorders. Overall, this meta-analysis demonstrated both peripapillary and macular structural retinal abnormalities in people with SZ or BD compared with HCs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
6秒前
28秒前
帅狗完成签到,获得积分10
32秒前
帅狗发布了新的文献求助10
34秒前
打打应助帅狗采纳,获得10
40秒前
42秒前
积极废物完成签到 ,获得积分10
50秒前
玄之又玄完成签到,获得积分10
1分钟前
2分钟前
2分钟前
2分钟前
2分钟前
一二完成签到 ,获得积分10
2分钟前
2分钟前
2分钟前
2分钟前
3分钟前
3分钟前
3分钟前
3分钟前
昒冥完成签到,获得积分10
3分钟前
1437594843完成签到 ,获得积分10
3分钟前
昒冥发布了新的文献求助10
3分钟前
ph完成签到 ,获得积分10
4分钟前
Kapur发布了新的文献求助100
4分钟前
4分钟前
4分钟前
5分钟前
5分钟前
Kapur完成签到,获得积分10
5分钟前
5分钟前
科目三应助涂烁采纳,获得30
5分钟前
5分钟前
pp完成签到,获得积分10
5分钟前
5分钟前
科目三应助ZXX采纳,获得10
5分钟前
5分钟前
5分钟前
5分钟前
5分钟前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2500
Востребованный временем 2500
Agaricales of New Zealand 1: Pluteaceae - Entolomataceae 1040
Healthcare Finance: Modern Financial Analysis for Accelerating Biomedical Innovation 1000
Classics in Total Synthesis IV: New Targets, Strategies, Methods 1000
지식생태학: 생태학, 죽은 지식을 깨우다 600
Neuromuscular and Electrodiagnostic Medicine Board Review 500
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 纳米技术 内科学 物理 化学工程 计算机科学 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 电极
热门帖子
关注 科研通微信公众号,转发送积分 3460124
求助须知:如何正确求助?哪些是违规求助? 3054392
关于积分的说明 9041963
捐赠科研通 2743751
什么是DOI,文献DOI怎么找? 1505215
科研通“疑难数据库(出版商)”最低求助积分说明 695610
邀请新用户注册赠送积分活动 694867