精子发生
无精子症
男性不育
生物
少精子症
男科
不育
精母细胞
基因
遗传学
内分泌学
减数分裂
医学
怀孕
作者
J. Zhang,Ruiqi Yan,Chau-Chung Wu,H. Wang,Gang Yang,Yuting Zhong,Y. Liu,Li Wan,Aifa Tang
出处
期刊:Andrologia
[Wiley]
日期:2018-04-26
卷期号:50 (6): e13027-e13027
被引量:10
摘要
Azoospermia, oligospermia and teratozoospermia all seriously impact male reproductive health. Spermatogenesis is a complex and precisely regulated process in which germ cells proliferate and differentiate and involves the regulation of multiple testis-specific genes. Here, we identified testis-specific gene spermatogenesis-associated 48 (SPATA48), the expression of which was age-dependent, indicating that it is involved in spermatogenesis. In humans and mice with azoospermia, expression of SPATA48 disappeared in the testis. Spata48-/- knockout male mice had smaller testis and defective spermatogenesis compared to wild-type (WT) mice. This study can help in the exploration of the genetic basis of male infertility and identify new targets for the diagnosis and treatment of male infertility.
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