阿霉素
生物相容性
钆
体内
纳米棒
毒品携带者
材料科学
生物医学工程
化学
药品
药理学
医学
纳米技术
化疗
内科学
有机化学
生物技术
生物
作者
Ying Liu,Yuxia Tang,Ying Tian,Jiang Wu,Jing Sun,Zhaogang Teng,Shouju Wang,Guangming Lu
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2019-01-24
卷期号:2 (3): 1194-1201
被引量:35
标识
DOI:10.1021/acsanm.8b02036
摘要
Hydroxyapatite nanoparticles have drawn much attention in the development of multifunctional nanosystems because of their excellent biocompatibility. In the report, gadolinium-doped hydroxyapatite nanorods (NHA:Gd) were controlled synthesized through adjusting the amount of gadolinium. The NHA:Gd showed a high loading capacity for doxorubicin (118 μg per milligram) and a pH-responsive drug release ability. The r1 value of obtained doxorubicin (DOX)-loaded NHA:Gd (NHA:Gd-DOX) solution reached 0.0472 (μg/mL)−1 s–1 and was higher than that of commercial T1 contrast Gd-DTPA (0.0314 (μg/mL)−1 s–1). In vivo experiments demonstrated that NHA:Gd-DOX exhibited excellent MR imaging property. The results of therapeutic efficacy demonstrate that the tumor volume treated by NHA:Gd-DOX was significantly reduced compared to that treated by free DOX. In vivo toxicity experiments demonstrated no obvious damage to the major organs in NHA:Gd-DOX treated mice. Considering the excellent biocompatibility, T1WI contrast ability, and enhanced therapeutic efficacy, these NHA:Gd-DOX have great potential for applications as MR T1 contrast agents and drug carriers for cancer therapy.
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