医学
皮疹
胃肠病学
内科学
不利影响
低蛋白血症
白细胞介素-3受体
白喉毒素
移植
免疫学
白血病
毒素
生物化学
化学
作者
Naveen Pemmaraju,Andrew A. Lane,Kendra Sweet,Anthony S. Stein,Sumithira Vasu,William Blum,David A. Rizzieri,Eunice S. Wang,Madeleine Duvic,J. Mark Sloan,Sharon Spence,Shay Shemesh,Chris Brooks,John Balser,Ivan Bergstein,Jeffrey E. Lancet,Hagop M. Kantarjian,Marina Konopleva
标识
DOI：10.1056/nejmoa1815105
摘要
Blastic plasmacytoid dendritic-cell neoplasm (BPDCN) is an aggressive hematologic cancer that is caused by transformed plasmacytoid dendritic cells that overexpress interleukin-3 receptor subunit alpha (IL3RA or CD123). Tagraxofusp (SL-401) is a CD123-directed cytotoxin consisting of human interleukin-3 fused to truncated diphtheria toxin.
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