对映选择合成
催化作用
试剂
化学
有机化学
酮
药物化学
作者
Jun Rong,Tilde Pellegrini,Syuzanna R. Harutyunyan
标识
DOI:10.1002/chem.201503412
摘要
Abstract Catalytic enantioselective addition of organometallic nucleophiles to ketones is among the most straightforward approaches to the synthesis of chiral tertiary alcohols. The first such catalytic methodologies using the highly reactive organomagnesium reagents, which are the preferred organometallic reagents in terms of cost, availability, atom efficiency, and structural diversity, were developed only during the last five years. This Concept article highlights the fundamental breakthrough that made the development of methodologies for highly enantioselective Cu I ‐catalyzed alkylation of ketones using organomagnesium reagents possible.
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