The first nucleophilic substitution reaction of organoindium reagents with sulfonyl chlorides: a facile method for preparation of vinyl sulfones

The first nucleophilic substitution reaction of organoindium with sulfonyl chlorides has been exploited.This reaction of vinylindium, derived from terminal alkynes via hydroindation, with sulfonyl chlorides in the presence of Ag 2 O provides access to vinyl sulfones.The vinyl sulfones were formed highly regio-and stereo-selectively with E stereochemistry.