趋化因子受体
CXCR4型
趋化因子
生物
免疫系统
免疫学
血管生成
受体
疾病
CCR10
信号转导
癌症研究
细胞生物学
医学
遗传学
内科学
作者
Tommaso Pozzobon,Giacomo Goldoni,Antonella Viola,Barbara Molon
标识
DOI:10.1016/j.imlet.2016.06.006
摘要
Chemokines and chemokine receptors regulate multiple processes such morphogenesis, angiogenesis and immune responses. Among the chemokine receptors, CXCR4 stands out for its pleiotropic roles as well as for its involvement in several pathological conditions, including immune diseases, viral infections and cancer. For these reasons, CXCR4 represents a crucial target in drug development. In this review, we discuss of CXCR4 receptor properties and signaling in health and diseases, focusing on the WHIM syndrome, an inherited immunodeficiency caused by mutations of the CXCR4 gene.
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