Cytotoxic and Anti-inflammatory Triterpenoids from Toona ciliata

Toonaciliatavarins A–H (1–8), including three new protolimonoids (1–3), two new tirucallane-type triterpenoids (4 and 5), and three new tetranortriterpenoids (6–8), and 10 known compounds were isolated from the stem barks of Toona ciliata Roem. var. henryi. Their structures were identified on the basis of spectroscopic analysis. The absolute configurations of 2 and 8 were determined by ECD calculation. The new isolates were evaluated for their cytotoxicities using six human cancer cell lines and also for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. Compounds 4 and 5 showed moderate cytotoxicities, and the protolimonoids (1–3) exhibited marked inhibitory effects on LPS-stimulated NO production.