化学
炔烃
吲哚试验
路易斯酸
亲核细胞
俘获
弗里德尔-克拉夫茨反应
组合化学
级联
有机化学
药物化学
催化作用
生态学
色谱法
生物
作者
Santosh J. Gharpure,Yogesh G. Shelke
出处
期刊:Organic Letters
[American Chemical Society]
日期:2017-09-22
卷期号:19 (19): 5406-5409
被引量:28
标识
DOI:10.1021/acs.orglett.7b02680
摘要
A Lewis acid promoted cascade Friedel-Craft/alkyne indol-2-yl cation cyclization/vinyl cation trapping for an efficient and divergent synthesis of N-fused indoles is developed. The present study illustrates the first example of an alkyne as a nucleophile on the less explored indol-2-yl cation. The method efficiently affords pharmaceutically important pyrrolizino-quinolines and complex fused indole derivatives in high yields.
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