Fusariocin C, a New Cytotoxic Substance Produced byFusarium moniliforme

A new cytotoxic substance, fusariocin C, was isolated from the culture filtrate of Fasarium moniliforme A–130. Fusariocin C, C27H28O6, forms pale yellow prisms, melting at 242–244°C and has an optical rotation of [α]20D − 20.6° (c=0.25, CHCl3). The ultraviolet absorption spectrum was observed at 258 and 365 nm. It was cytotoxic to HeLa cell culture and leukemia L 1210 cells, and showed some anti-tumor activity in vivo for ascitic form of Ehrlich carcinoma. The LD50 by intraperitoneal injection in mice was determined to be 3.97 mg/kg. This compound was almost devoid of antimicrobial activity.