已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Recent Progress in Chemical Modifications of Chlorophylls and Bacteriochlorophylls for the Applications in Photodynamic Therapy

光动力疗法 化学 细菌叶绿素 光敏剂 单线态氧 背景(考古学) 光毒性 组合化学 纳米技术 光化学 有机化学 颜料 生物化学 材料科学 生物 古生物学 体外 氧气
作者
Jakub Staroń,Bożena Boroń,Dariusz Karcz,Małgorzata Szczygieł,Leszek Fiedor
出处
期刊:Current Medicinal Chemistry [Bentham Science]
卷期号:22 (26): 3054-3074 被引量:29
标识
DOI:10.2174/0929867322666150818104034
摘要

Since photodynamic therapy emerged as a promising cancer treatment, the development of photosensitizers has gained great interest. In this context, the photosynthetic pigments, chlorophylls and bacteriochlorophylls, as excellent natural photosensitizers, attracted much attention. In effect, several (bacterio) chlorophyll-based phototherapeutic agents have been developed and (or are about to) enter the clinics. The aim of this review article is to give a survey of the advances in the synthetic chemistry of these pigments which have been made over the last decade, and which are pertinent to the application of their derivatives as photosensitizers for photodynamic therapy (PDT). The review focuses on the synthetic strategies undertaken to obtain novel derivatives of (bacterio)chlorophylls with both enhanced photosensitizing and tumorlocalizing properties, and also improved photo- and chemical stability. These include modifications of the C- 17-ester moiety, the isocyclic ring, the central binding pocket, and the derivatization of peripheral functionalities at the C-3 and C-7 positions with carbohydrate-, peptide-, and nanoparticle moieties or other residues. The effects of these modifications on essential features of the pigments are discussed, such as the efficiency of reactive oxygen species generation, photostability, phototoxicity and interactions with living organisms. The review is divided into several sections. In the first part, the principles of PDT and photosensitizer action are briefly described. Then the relevant photophysical features of (bacterio)chlorophylls and earlier approaches to their modification are summarized. Next, a more detailed overview of the progress in synthetic methods is given, followed by a discussion of the effects of these modifications on the photophysics of the pigments and on their biological activity. Keywords: Bacteriochlorophyll, biological activity, chlorophyll, modifications, photodynamic therapy, photosensitizers, reactive oxygen species, tumor imaging, tumor targeting.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wcy完成签到 ,获得积分10
刚刚
杭子轩应助迪丽热巴采纳,获得30
刚刚
刚刚
Leif应助啵子采纳,获得20
刚刚
大模型应助zzzzzzy采纳,获得10
2秒前
wao完成签到 ,获得积分10
3秒前
金灶沐完成签到 ,获得积分10
3秒前
Hello应助dh采纳,获得10
4秒前
fareless完成签到 ,获得积分10
5秒前
小丽酱完成签到 ,获得积分10
5秒前
7秒前
8秒前
atcha完成签到 ,获得积分10
9秒前
吕半鬼完成签到,获得积分10
9秒前
AnJaShua完成签到 ,获得积分10
11秒前
Hyg完成签到 ,获得积分10
12秒前
wangwang完成签到 ,获得积分10
12秒前
13秒前
杭子轩应助迪丽热巴采纳,获得30
13秒前
spc发布了新的文献求助10
14秒前
科研一霸发布了新的文献求助10
14秒前
火翟丰丰山心完成签到,获得积分10
15秒前
16秒前
文欣完成签到 ,获得积分10
16秒前
Fern完成签到 ,获得积分10
17秒前
17秒前
深情安青应助谢云云采纳,获得10
18秒前
科研通AI5应助sunnyfish007采纳,获得10
18秒前
辛勤的剑成完成签到 ,获得积分10
19秒前
慕青应助科研一霸采纳,获得10
19秒前
春辞完成签到,获得积分10
20秒前
lzc发布了新的文献求助10
20秒前
称心的语梦完成签到,获得积分10
22秒前
22秒前
Owen应助独一无二采纳,获得10
23秒前
orange9完成签到,获得积分10
26秒前
tiancu完成签到,获得积分10
26秒前
27秒前
27秒前
笨笨完成签到,获得积分10
29秒前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Population Genetics 3000
Continuum thermodynamics and material modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Unseen Mendieta: The Unpublished Works of Ana Mendieta 1000
Theory of Block Polymer Self-Assembly 750
지식생태학: 생태학, 죽은 지식을 깨우다 700
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 纳米技术 内科学 物理 化学工程 计算机科学 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 电极
热门帖子
关注 科研通微信公众号,转发送积分 3497285
求助须知:如何正确求助?哪些是违规求助? 3081852
关于积分的说明 9169340
捐赠科研通 2774991
什么是DOI,文献DOI怎么找? 1522692
邀请新用户注册赠送积分活动 706207
科研通“疑难数据库(出版商)”最低求助积分说明 703234