High fat diet induced abnormalities in metabolism, growth, behavior, and circadian clock in Drosophila melanogaster

昼夜节律 生物 黑腹果蝇 生物钟 内科学 内分泌学 胰岛素抵抗 时钟 碳水化合物代谢 脂质代谢 胰岛素 基因 遗传学 医学
作者
Nibedita Nayak,Monalisa Mishra
出处
期刊:Life Sciences [Elsevier BV]
卷期号:281: 119758-119758 被引量:29
标识
DOI:10.1016/j.lfs.2021.119758
摘要

Abstract Aims The current lifestyle trend has made people vulnerable to diabetes and related diseases. Years of scientific research have not been able to yield a cure to the disease completely. The current study aims to investigate a link between high-fat diet mediated diabesity and circadian rhythm in the Drosophila model and inferences that might help in establishing a cure to the dreaded disease. Main methods Several experimental methods including phenotypical, histological, biochemical, molecular, and behavioral assays were used in the study to detect obesity, diabetes, and changes in the circadian clock in the fly model. Key findings The larva and adults of Drosophila melanogaster exposed to high-fat diet (HFD) displayed excess deposition of fat as lipid droplets and micronuclei formation in the gut, fat body, and crop. Larva and adults of HFD showed behavioral defects. The higher amount of triglyceride, glucose, trehalose in the whole body of larva and adult fly confirmed obesity-induced hyperglycemia. The overexpression of insulin gene (Dilp2) and tribble (trbl) gene expression confirmed insulin resistance in HFD adults. We also observed elevated ROS level, developmental delay, altered metal level, growth defects, locomotory rhythms, sleep fragmentation, and expression of circadian genes (per, tim, and clock) in HFD larva and adults. Thus, HFD impairs the metabolism to produce obesity, insulin resistance, disruption of clock, and circadian clock related co-mordities in D. melanogaster. Significance The circadian gene expression provides an innovative perspective to understand and find a new treatment for type-II diabetes and circadian anomalies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
情怀应助小梦采纳,获得10
刚刚
科研土狗发布了新的文献求助10
刚刚
大憨憨完成签到 ,获得积分10
2秒前
苹果王子6699完成签到 ,获得积分10
3秒前
Niyuw发布了新的文献求助10
3秒前
Xiaoxiao发布了新的文献求助20
5秒前
醉熏的鑫发布了新的文献求助10
6秒前
迅速海云完成签到,获得积分10
6秒前
6秒前
栗子的小母牛完成签到,获得积分10
7秒前
dh完成签到,获得积分10
10秒前
岩墩墩完成签到,获得积分10
11秒前
克姑美完成签到 ,获得积分10
14秒前
pangao完成签到,获得积分10
14秒前
ysssbq完成签到,获得积分10
16秒前
17秒前
上好佳完成签到 ,获得积分10
17秒前
大模型应助Yeong采纳,获得10
18秒前
量子星尘发布了新的文献求助30
18秒前
19秒前
123完成签到,获得积分10
19秒前
谢陈完成签到 ,获得积分10
20秒前
lilili完成签到,获得积分10
21秒前
22秒前
xiaoying发布了新的文献求助10
22秒前
SciGPT应助Eric_Liuzy采纳,获得10
23秒前
liu完成签到 ,获得积分10
23秒前
qixiaoqi发布了新的文献求助10
24秒前
25秒前
A溶大美噶发布了新的文献求助10
25秒前
26秒前
26秒前
27秒前
28秒前
29秒前
kevin发布了新的文献求助10
29秒前
满意的初南完成签到 ,获得积分10
30秒前
橙橙橙发布了新的文献求助10
30秒前
万能图书馆应助EVEN采纳,获得10
30秒前
30秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038569
求助须知:如何正确求助?哪些是违规求助? 3576279
关于积分的说明 11374944
捐赠科研通 3305979
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815048