High fat diet induced abnormalities in metabolism, growth, behavior, and circadian clock in Drosophila melanogaster

昼夜节律 生物 黑腹果蝇 生物钟 内科学 内分泌学 胰岛素抵抗 时钟 碳水化合物代谢 脂质代谢 胰岛素 基因 遗传学 医学
作者
Nibedita Nayak,Monalisa Mishra
出处
期刊:Life Sciences [Elsevier BV]
卷期号:281: 119758-119758 被引量:29
标识
DOI:10.1016/j.lfs.2021.119758
摘要

Abstract Aims The current lifestyle trend has made people vulnerable to diabetes and related diseases. Years of scientific research have not been able to yield a cure to the disease completely. The current study aims to investigate a link between high-fat diet mediated diabesity and circadian rhythm in the Drosophila model and inferences that might help in establishing a cure to the dreaded disease. Main methods Several experimental methods including phenotypical, histological, biochemical, molecular, and behavioral assays were used in the study to detect obesity, diabetes, and changes in the circadian clock in the fly model. Key findings The larva and adults of Drosophila melanogaster exposed to high-fat diet (HFD) displayed excess deposition of fat as lipid droplets and micronuclei formation in the gut, fat body, and crop. Larva and adults of HFD showed behavioral defects. The higher amount of triglyceride, glucose, trehalose in the whole body of larva and adult fly confirmed obesity-induced hyperglycemia. The overexpression of insulin gene (Dilp2) and tribble (trbl) gene expression confirmed insulin resistance in HFD adults. We also observed elevated ROS level, developmental delay, altered metal level, growth defects, locomotory rhythms, sleep fragmentation, and expression of circadian genes (per, tim, and clock) in HFD larva and adults. Thus, HFD impairs the metabolism to produce obesity, insulin resistance, disruption of clock, and circadian clock related co-mordities in D. melanogaster. Significance The circadian gene expression provides an innovative perspective to understand and find a new treatment for type-II diabetes and circadian anomalies.
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