生物
免疫系统
细胞生物学
获得性免疫系统
先天性淋巴细胞
树突状细胞
周边公差
细胞分化
T细胞
抗原提呈细胞
细胞毒性T细胞
滤泡树突状细胞
免疫学
体外
遗传学
基因
作者
Xiangyun Yin,Shuting Chen,Stephanie C. Eisenbarth
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2021-03-12
卷期号:39 (1): 759-790
被引量:212
标识
DOI:10.1146/annurev-immunol-101819-025146
摘要
As the professional antigen-presenting cells of the immune system, dendritic cells (DCs) sense the microenvironment and shape the ensuing adaptive immune response. DCs can induce both immune activation and immune tolerance according to the peripheral cues. Recent work has established that DCs comprise several phenotypically and functionally heterogeneous subsets that differentially regulate T lymphocyte differentiation. This review summarizes both mouse and human DC subset phenotypes, development, diversification, and function. We focus on advances in our understanding of how different DC subsets regulate distinct CD4+ T helper (Th) cell differentiation outcomes, including Th1, Th2, Th17, T follicular helper, and T regulatory cells. We review DC subset intrinsic properties, local tissue microenvironments, and other immune cells that together determine Th cell differentiation during homeostasis and inflammation.
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