[PI3K/Akt/mTOR signal pathway in endocrine disrupting chemicals-induced apoptosis and autophagy of thyroid follicular cells].

Endocrine disrupting chemicals (EDCs) are a kind of exogenous chemicals widely existing in the environment, which cause serious harm to the environment and human health. At present, the impact of this type of substance on the thyroid has attracted much attention.This review summarized the effects of EDCs on thyroid hormones, and phosphatidylinositol 3-kinase (PI3K) /protein kinase B (Akt) /mammalian target of rapamycin (mTOR) (PI3K/Akt/mTOR) signaling pathway and its role in thyroid diseases, and explore the role of PI3K/Akt/mTOR signaling pathway in EDCs-induced apoptosis and autophagy of thyroid follicular epithelial cells.This paper could provide further understandings for thyroid diseases induced by the autophagy and apoptosis of thyroid follicular epithelial cells.环境内分泌干扰物（endocrine disrupting chemicals，EDCs）是广泛存在于环境中对环境和人类健康造成严重危害的一类外源性化学物质，目前机体暴露该类物质对甲状腺的影响备受关注。我们综述了环境内分泌干扰物对甲状腺激素的影响，磷脂酰肌醇3-激酶（phosphatidylinositol 3-kinase，PI3K）/蛋白激酶B（protein kinase B，Akt）/哺乳动物雷帕霉素靶蛋白（mammalian target of rapamycin，mTOR）（PI3K/Akt/mTOR）信号转导途径在甲状腺疾病中的作用以及PI3K/Akt/mTOR信号通路在EDCs诱导甲状腺滤泡上皮细胞凋亡和自噬中的作用，为相关的甲状腺疾病提供进一步的认识。.