丝素
材料科学
生物相容性材料
电极
神经活动
自愈水凝胶
丝绸
电极阵列
导电体
神经工程
生物医学工程
纳米技术
计算机科学
复合材料
神经科学
化学
工程类
物理化学
生物
人工智能
高分子化学
作者
Jie Ding,Zhihong Chen,Xiaoyin Liu,Yuan Tian,Ji Jiang,Zi Qiao,Yusheng Zhang,Zhanwen Xiao,Dan Wei,Jing Sun,Fang Luo,Liangxue Zhou,Hongsong Fan
出处
期刊:Materials horizons
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:9 (8): 2215-2225
被引量:26
摘要
A flexible non-transient electrical platform that can realize bidirectional neural communication from living tissues is of great interest in neuroscience to better understand basic neuroscience and the nondrug therapy of diseases or disorders. The development of soft, biocompatible, and conductive neural interface with mechanical coupling and efficient electrical exchange is a new trend but remains a challenge. Herein, we designed a multifunctional neural electrical communication platform in the form of a mechanically compliant, electrically conductive, and biocompatible hydrogel electrode. Silk fibroin (SF) obtained from Bombyx Mori cocoons was compounded with aldehyde-hyaluronic acid (HA-CHO) with a dynamic network to delay or interrupt the β-sheet-induced hardening of SF chains, resulting in the fabrication of a hydrogel matrix that is mechanically matched to biological tissues. Moreover, the incorporation of functionalized carbon nanotubes (CNTs) facilitated interaction and dispersion and enabled the formation of a hydrogel electrode with a high-current percolation network, thus contributing toward improving the electrical properties in terms of conductivity, impedance, and charge storage capabilities. These advances allow high-efficiency stimulation and the recording of neural signals during in vivo implantation. Overall, a wide range of animal experiments demonstrate that the platform exhibits minimal foreign body responses, thus showing it to be a promising electrophysiology interface for potential applications in neuroscience.
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