楔前
医学
减肥
袖状胃切除术
功能连接
脑岛
后扣带
内科学
肥胖
心脏病学
认知
神经科学
心理学
胃分流术
精神科
作者
Jia Wang,Guanya Li,Yang Hu,Wenchao Zhang,Lei Zhang,Zongxin Tan,Hao Li,Zhenzhen Jia,Karen M. von Deneen,Xiaohua Li,Juan Yu,Yu Han,Guangbin Cui,Peter Manza,Ehsan Shokri‐Kojori,Dardo Tomasi,Nora D. Volkow,Yongzhan Nie,Gang Ji,Yi Zhang,Gene‐Jack Wang
出处
期刊:Obesity
[Wiley]
日期:2021-12-08
卷期号:30 (1): 172-182
被引量:4
摘要
The aim of this study was to investigate laparoscopic sleeve gastrectomy (LSG)-induced changes in connectivity between regions involved with reward/antireward and cognitive control and the extent to which these changes persist after surgery and predict sustainable weight loss.Whole-brain local functional connectivity density (lFCD) was studied in 25 participants with obesity who underwent resting-state functional MRI before (PreLSG), 1 month after (PostLSG1 ), and 12 months after (PostLSG12 ) LSG and compared with 25 normal-weight controls. Regions with significant time effects of LSG on functional connectivity density were identified for subsequent seed-based connectivity analyses and to examine associations with behavior.LSG significantly increased lFCD in the mediodorsal thalamic nucleus (MD) and in the habenula (Hb) at PostLSG12 compared with PreLSG/PostLSG1 , whereas it decreased lFCD in the posterior cingulate cortex/precuneus (PCC/PreCun) at PostLSG1 /PostLSG12 , and these changes were associated with reduction in BMI. In contrast, controls had no significant lFCD differences between baseline and repeated measures. MD had stronger connectivity with PreCun and Hb at PostLSG12 compared with PreLSG/PostLSG1 , and the increased MD-left PreCun and Hb-MD connectivity correlated with decreases in hunger and BMI, respectively. PCC/PreCun had stronger connectivity with the insula at PostLSG1-12 .The findings highlight the importance of reward and interoceptive regions as well as that of regions mediating negative emotions in the long-term therapeutic benefits of LSG.
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