Augmenting the synergies of chemotherapy and immunotherapy through drug delivery

化学免疫疗法 免疫疗法 医学 化疗 佐剂 癌症 纳米载体 药物输送 癌症免疫疗法 药品 免疫系统 肿瘤科 免疫学 药理学 内科学 材料科学 纳米技术
作者
Jihoon Kim,Margaret P. Manspeaker,Susan N. Thomas
出处
期刊:Acta Biomaterialia [Elsevier]
卷期号:88: 1-14 被引量:30
标识
DOI:10.1016/j.actbio.2019.02.012
摘要

Despite the recent approvals of multiple cancer immunotherapies, low tumor immunogenicity and immunosuppressive tumor microenvironments prevent a large portion of patients from responding to these treatment modalities. Given the immunomodulatory and adjuvant effects of conventional chemotherapy as well as its widespread clinical use, the use of chemotherapy in combination with immunotherapy (so-called chemoimmunotherapy) is an attractive approach to potentiate the effects of immunotherapy in more patient populations. However, due to the limited extent of tumor accumulation, poorly controlled interactions with the immune system, and effects on systemic healthy tissues by chemotherapeutic drugs, the incorporation of anti-cancer agents into biomaterial-based structures, such as nanocarriers, is highly attractive to improve the safety and efficacy of chemoimmunotherapy. Herein, we review the recent progress in drug delivery systems (DDSs) for potentiating the immunomodulatory effects of chemotherapeutics in chemoimmunotherapy, which represent among the most promising next generation strategies for cancer treatment in the immunotherapy era. STATEMENT OF SIGNIFICANCE: Given the benefits of cancer immunotherapy in inducing durable, albeit low rates, of patient response, interest in the immunomodulatory and adjuvant effects of conventional chemotherapy has been re-invigorated. This review article discusses the recent progress towards understanding the synergies between these two treatment types, how they can be used in combination (so-called chemoimmunotherapy), and the potential for drug delivery systems to optimize their effects in translational settings.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Tyche完成签到,获得积分10
刚刚
Masvidog完成签到,获得积分10
刚刚
缥缈千风完成签到,获得积分10
1秒前
科研通AI2S应助刚刚好采纳,获得30
1秒前
1秒前
科研通AI5应助77采纳,获得10
1秒前
听闻墨笙完成签到,获得积分10
1秒前
个性尔槐完成签到,获得积分10
1秒前
深情安青应助susu采纳,获得10
1秒前
wp2002发布了新的文献求助10
2秒前
科研通AI5应助钟迪采纳,获得10
2秒前
英姑应助金木水火土采纳,获得10
2秒前
喻辰星发布了新的文献求助10
3秒前
3秒前
3秒前
3秒前
淼鑫完成签到,获得积分10
3秒前
图图完成签到,获得积分20
3秒前
4秒前
llzuo发布了新的文献求助10
4秒前
4秒前
haomozc发布了新的文献求助10
5秒前
runpeng完成签到,获得积分10
5秒前
5秒前
6秒前
kelip完成签到,获得积分10
6秒前
lalala发布了新的文献求助10
6秒前
Zpeao发布了新的文献求助10
6秒前
bkagyin应助美丽迎梦采纳,获得10
6秒前
柠檬杨完成签到,获得积分10
6秒前
LTY完成签到,获得积分10
6秒前
ZeradesY完成签到,获得积分10
7秒前
花开不败发布了新的文献求助10
8秒前
8秒前
喜悦谷秋发布了新的文献求助10
8秒前
迅速的萧完成签到 ,获得积分10
8秒前
8秒前
9秒前
9秒前
落后以旋完成签到,获得积分10
10秒前
高分求助中
Continuum Thermodynamics and Material Modelling 4000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Unseen Mendieta: The Unpublished Works of Ana Mendieta 1000
El viaje de una vida: Memorias de María Lecea 800
Theory of Block Polymer Self-Assembly 750
Luis Lacasa - Sobre esto y aquello 700
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3512007
求助须知:如何正确求助?哪些是违规求助? 3094539
关于积分的说明 9223579
捐赠科研通 2789383
什么是DOI,文献DOI怎么找? 1530667
邀请新用户注册赠送积分活动 711041
科研通“疑难数据库(出版商)”最低求助积分说明 706513