光学
各向同性
材料科学
各向异性
显微镜
生物标本
图像分辨率
核磁共振
分辨率(逻辑)
物理
计算机科学
人工智能
作者
De Cai,Terence T. W. Wong,Liren Zhu,Junhui Shi,Sung‐Liang Chen,Lihong V. Wang
出处
期刊:Optics Letters
[The Optical Society]
日期:2018-10-01
卷期号:43 (20): 4875-4875
被引量:31
摘要
Optical-resolution photoacoustic microscopy (OR-PAM) is an emerging imaging modality for studying biological tissues. However, in conventional single-view OR-PAM, the lateral and axial resolutions-determined optically and acoustically, respectively-are highly anisotropic. In this Letter, we introduce dual-view OR-PAM to improve axial resolution, achieving three-dimensional (3D) resolution isotropy. We first use 0.5 μm polystyrene beads and carbon fibers to validate the resolution isotropy improvement. Imaging of mouse brain slices further demonstrates the improved resolution isotropy, revealing the 3D structure of cell nuclei in detail, which facilitates quantitative cell nuclear analysis.
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